70127
纳洛酮盐酸盐二水合物 盐酸盐 二水合物
≥99.0% (TLC)
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关于此项目
经验公式（希尔记法）:
C19H21NO4 · HCl · 2H2O
化学文摘社编号:
分子量:
399.87
EC Number:
201-447-6
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
6260807
InChI
1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
InChI key
TXMZWEASFRBVKY-IOQDSZRYSA-N
SMILES string
O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
assay
≥99.0% (TLC)
storage temp.
2-8°C
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Application
Displaces morphine and other opiate agonists from the opiate receptor. In studies on the opiate receptor
Other Notes
Potent opiate antagonist.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
C Mollereau et al.
The Journal of biological chemistry, 263(34), 18003-18008 (1988-12-05)
When assayed for specific opiate binding in the presence of 120 mM NaCl, digitonin extracts from frog (Rana ridibunda) brain membranes were found to contain about the same quantity (0.5 pmol/mg of protein) of high (Kdh = 0.4 nM) and
T Costa et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7321-7325 (1989-10-01)
According to classical models of drug-receptor interactions, competitive antagonists share with agonists the ability to bind to a common site on the receptor molecule. However, they are different from agonists, as they cannot trigger the "stimulus" that leads to biological
Yumei Liu et al.
PloS one, 8(1), e51573-e51573 (2013-02-06)
Previously, we demonstrated that electroacupuncture (EA) decreased lymphocyte infiltration into the spinal cords of rats presenting with experimental autoimmune encephalomyelitis (EAE), a disease model used in the study of multiple sclerosis (MS). The aim of this study was to characterize
Delia Aguado et al.
Anesthesiology, 118(5), 1160-1169 (2013-02-15)
Opioid antagonists at ultra-low doses have been used with opioid agonists to prevent or limit opioid tolerance. The aim of this study was to evaluate whether an ultra-low dose of naloxone combined with remifentanil could block opioid-induced hyperalgesia and tolerance
Opiate receptor antagonists for treatment of severe pruritus associated with advanced cholestatic liver disease.
Nilay Kumar et al.
Journal of palliative medicine, 16(2), 122-123 (2013-02-09)
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