72345
烟酰胺
synthetic, ≥98.5% (HPLC), PARP inhibitor, powder
别名:
吡啶-3-甲酰胺, 烟碱酰胺, 烟酰胺, 维生素 B3, 维生素 PP
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关于此项目
经验公式（希尔记法）:
C6H6N2O
化学文摘社编号:
分子量:
122.12
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
202-713-4
MDL number:
Beilstein/REAXYS Number:
383619
产品名称
烟酰胺, ≥98.5% (HPLC)
InChI key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
SMILES string
NC(=O)c1cccnc1
biological source
synthetic
assay
≥98.5% (HPLC)
form
powder
color
colorless to white
mp
128-131 °C (lit.)
128-131 °C
Quality Level
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Application
烟酰胺已被用于：
- 在对NAD缺陷哺乳动物线粒体中，研究其作为前体对烟酰胺腺嘌呤二核苷酸 (NAD) 浓度的影响
- 在体外丝氨酸羟甲基转移酶2 (SHMT2) 脱乙酰分析中，作为脱乙酰酶sirtuin (SIRT) 蛋白家族的抑制剂
- 研究其对ptenαm/m小鼠中缺血再灌注损伤诱导细胞死亡的影响
Biochem/physiol Actions
烟酰胺可作为生产β-烟酰胺腺嘌呤二核苷酸 (NAD+) 辅酶的前体。它参与NAD+磷酸盐 (NADP+) 的合成。它还调节细胞存活和死亡机制。烟酰胺缺乏症的症状包括疲劳、皮肤色素沉着、食欲下降和口腔溃疡。它的慢性缺乏会导致糙皮病。烟酰胺有减少氧化应激的保护作用。
烟酰胺是维生素B3的酰胺衍生物，是PARP抑制剂
General description
烟酰胺由烟酸在肝脏中合成。它还能通过烟酰胺腺嘌呤二核苷酸 (NAD+) 水解生成。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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