75580
原乙酸三乙酯
purum, ≥98.0% (GC)
别名:
1,1,1-三乙氧基乙烷
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关于此项目
线性分子式:
CH3C(OC2H5)3
化学文摘社编号:
分子量:
162.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
201-112-4
Beilstein/REAXYS Number:
506201
MDL number:
产品名称
原乙酸三乙酯, purum, ≥98.0% (GC)
InChI key
NDQXKKFRNOPRDW-UHFFFAOYSA-N
InChI
1S/C8H18O3/c1-5-9-8(4,10-6-2)11-7-3/h5-7H2,1-4H3
SMILES string
CCOC(C)(OCC)OCC
grade
purum
assay
≥98.0% (GC)
form
liquid
refractive index
n20/D 1.396 (lit.)
n20/D 1.396
bp
142 °C (lit.)
density
0.885 g/mL at 25 °C (lit.)
functional group
ether
Quality Level
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Application
Triethyl orthoacetate is a general reagent used to functionalize alcohols with acetate groups. It can be used in following reactions:
- Stereocontrolled total synthesis of a naturally occuring indole alkaloid, (−)-aspidophytine.
- Conversion of allylic alcohols to γ,δ-unsaturated esters under mild acidic condition, a reaction popularly known as Johnson–Claisen rearrangement.
- Synthesis of heterocycles such as 2-oxazolines and quinazolin-4(3H)-one derivatives.
Simple stereoselective version of the Claisen rearrangement leading to trans-trisubstituted olefinic bonds. Synthesis of squalene.
Johnson WS, et al.
Journal of the American Chemical Society, 92(3), 741-743 (1970)
Reaction of orthoesters with alcohols in the presence of acidic catalysts: A study.
Kumar, HM et al.
Indian J. Chem. B, 44B(8), 1686-1692 (2005)
Stereocontrolled total synthesis of (−)-aspidophytine.
Sumi S, et al.
Tetrahedron, 59(43), 8571-8587 (2003)
An efficient and versatile method for the synthesis of optically active 2-oxazolines: an acid-catalyzed condensation of ortho esters with amino alcohols.
Kamata K, et al.
The Journal of Organic Chemistry, 63(9), 113-3116 (1998)
Clay catalysis: condensation of orthoesters with O-substituted aminoaromatics into heterocycles.
Villemin D, et al.
Synthetic Communications, 26(15), 2895-2899 (1996)
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