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78246

姜黄素

Name: 姜黄素
Brand: SIAL

matrix substance for MALDI-MS, ≥99.5% (HPLC)

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别名:

(E,E)-1,7-双(4-羟基-3-甲氧基苯基)-1,6-庚二烯-3,5-二酮, 二阿魏酸甲烷, 天然黄3

线性分子式:

[HOC₆H₃(OCH₃)CH=CHCO]₂CH₂

CAS号:

458-37-7

分子量:

368.38

颜色索引号:

75300

Beilstein:

2306965

EC 号:

207-280-5

MDL编号:

MFCD00008365

PubChem化学物质编号:

329768129

NACRES:

NA.21

等级

matrix substance for MALDI-MS

质量水平

100

蒸汽密度

13 (vs air)

检测方案

≥99.5% (HPLC)

形式

powder

技术

MALDI-MS: suitable

mp

183-188 °C

痕量阳离子

Na: ≤50 mg/kg

储存温度

2-8°C

SMILES字符串

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI

1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI key

VFLDPWHFBUODDF-FCXRPNKRSA-N

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生化/生理作用

一种天然酚类化合物。它是有效的抗肿瘤剂，具有抗炎和抗氧化活性。除了具有化疗活性外，姜黄素还被认为是潜在的化学预防剂。它能够诱导癌细胞凋亡并抑制佛波酯诱导的蛋白激酶C（PKC）活性。据报道，它能抑制外周血单核细胞和肺泡巨噬细胞产生炎性细胞因子。它是EGFR酪氨酸激酶和IκB激酶的有效抑制剂。它能抑制诱导型一氧化氮合酶（iNOS）、环加氧酶和脂氧合酶。它易于渗透到细胞质中，在质膜、内质网和核膜等膜结构中积累。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer.

Michal Heger et al.

Pharmacological reviews, 66(1), 222-307 (2013-12-26)

This review addresses the oncopharmacological properties of curcumin at the molecular level. First, the interactions between curcumin and its molecular targets are addressed on the basis of curcumin's distinct chemical properties, which include H-bond donating and accepting capacity of the

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Issac Abraham Sybiya Vasantha Packiavathy et al.

Food chemistry, 148, 453-460 (2013-11-23)

Urinary tract infection is caused primarily by the quorum sensing (QS)-dependent biofilm forming ability of uropathogens. In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such

Curcumin as a regulator of epigenetic events.

Marie-Hélène Teiten et al.

Molecular nutrition & food research, 57(9), 1619-1629 (2013-06-12)

Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as

Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.

Bharat B Aggarwal et al.

Molecular nutrition & food research, 57(9), 1529-1542 (2013-07-13)

Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic

Coadministration of erlotinib and curcumin augmentatively reduces cell viability in lung cancer cells.

Yoshikane Yamauchi et al.

Phytotherapy research : PTR, 28(5), 728-735 (2013-08-15)

Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways in association

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姜黄素