80073
α-Hydroxymetoprolol
analytical standard
别名:
3-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-1-isopropylamino-2-propanol, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-α-(methoxymethyl)-benzenemethanol
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关于此项目
经验公式（希尔记法）:
C15H25NO4
化学文摘社编号:
分子量:
283.36
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6571082
InChI
1S/C15H25NO4/c1-11(2)16-8-13(17)9-20-14-6-4-12(5-7-14)15(18)10-19-3/h4-7,11,13,15-18H,8-10H2,1-3H3
SMILES string
OC(CNC(C)C)COC1=CC=C(C(O)COC)C=C1
InChI key
OFRYBPCSEMMZHR-UHFFFAOYSA-N
grade
analytical standard
assay
≥98.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
68-74 °C
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
B Everts et al.
European journal of clinical pharmacology, 53(1), 23-31 (1997-01-01)
Pain intensity and the plasma concentrations of metoprolol and its major metabolite alpha-hydroxymetoprolol as well as noradrenaline (NA), adrenaline (A) and neuropeptide Y (NPY) were determined in patients with pain due to definite or suspected acute myocardial infarction (AMI) after
Diego Alberto Ciscato Cusinato et al.
Journal of pharmaceutical and biomedical analysis, 164, 430-441 (2018-11-18)
Drug transporters and CYP enzymes are important sources of pharmacokinetics (PK) variability in drug responses and can cause various pharmacological and toxicological consequences, leading to either toxicity or an insufficient pharmacological effect. In recent years, the cocktail approach was developed
Nattee Sirisuth et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 53(3), 301-309 (2002-04-27)
To investigate the influence of alpha-hydroxymetoprolol (AHM) and 4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid (ACMB), both derived from its first pass metabolism of metoprolol, an in vitro in vivo correlation incorporating first pass metabolite data for metoprolol extended release formulations was developed. Three different
Paula Macedo Cerqueira et al.
Chirality, 15(6), 542-549 (2003-05-30)
Direct stereoselective separation on chiral stationary phase was developed for HPLC analysis of the four stereoisomers of alpha-hydroxymetoprolol in human plasma and urine. Plasma samples were prepared using solid-phase extraction columns and urine samples were prepared by liquid-liquid extraction. The
Vanessa Bergamin Boralli et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 823(2), 195-202 (2005-07-21)
We investigated the stereoselective kinetic disposition and metabolism of metoprolol (MET) in rats. The racemic MET (15 mg/kg) was given by oral gavage and blood samples were collected from 0 to 10h (n=6 at each time point). The enantiomeric concentrations
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