80126
N-叔丁基-α-苯基硝酮
for ESR-spectroscopy
别名:
N-苯亚甲基-叔丁胺-N-氧化物, PBN, 苯基·N-叔丁基硝酮
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关于此项目
线性分子式:
C6H5CH=N(O)C(CH3)3
化学文摘社编号:
分子量:
177.24
Beilstein:
2044028
EC 号:
MDL编号:
UNSPSC代码:
23151816
PubChem化学物质编号:
NACRES:
NA.21
质量水平
方案
≥99.5% (HPLC)
表单
powder
mp
72-74 °C
73-74 °C (lit.)
溶解性
chloroform: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
CC(C)(C)[N+](\[O-])=C\c1ccccc1
InChI
1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChI key
IYSYLWYGCWTJSG-XFXZXTDPSA-N
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应用
用 EPR 自旋捕捉技术测定类胡萝卜素清除速率常数时，用 N-叔丁基苯基硝酮作为自旋捕捉剂。该试剂有助于获得六线 ESR 谱和超精细耦合常数，使用电子自旋共振光谱和液相色谱质谱法证实尿酸和过氧亚硝基中存在碳基自由基。
生化/生理作用
N-叔丁基-α-苯基硝酮（PBN）是一种常用的自由基自旋捕获剂。
N-叔丁基-α-苯基硝酮（PBN）是一种常用的自由基自旋捕获剂。已有研究表明，PBN具有自由基清除活性以及抑制环氧合酶-2活性的能力，因此，它可以减少兔皮质中栓子诱导的脑微梗死的数量并预防肿瘤形成。据报道，PBN可抑制诱导型一氧化氮合酶（iNOS），从而防止一氧化氮（NO）过量产生。 PBN以100 mg/kg腹腔注射，可减少氟替尔诱导大鼠癫痫持续状态中的黑质网状部坏死。它可以预防癫痫动物模型中某些类型的创伤后致癫痫事件。已有研究发现，大鼠的PBN致死剂量约为100 mg/100 g体重（0.564 mmol/100Å g）。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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