80709
隐丹参酮
analytical standard
别名:
(R)-(−)-1,6,6-三甲基-1,2,6,7,8,9-六氢菲并[1,2-b]呋喃-10,11-二酮, 丹参酮C
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关于此项目
经验公式（希尔记法）:
C19H20O3
化学文摘社编号:
分子量:
296.36
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5445400
InChI
1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
SMILES string
C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23
InChI key
GVKKJJOMQCNPGB-JTQLQIEISA-N
grade
analytical standard
assay
≥97.0% (HPLC)
optical activity
[α]/D -85.0±3.0°, c = 0.1 in chloroform
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
food and beverages
format
neat
storage temp.
2-8°C
Quality Level
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General description
隐丹参酮是一种从丹参中分离得到生物活性物质，属于丹参酮类化合物，具有抗菌、抗炎、抗肿瘤等多种广谱治疗作用。
Application
有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。
隐丹参酮可作为分析参考标准品，通过不同色谱技术对生物学样品和药物制剂中的分析物进行定量。
Biochem/physiol Actions
隐丹参酮是一种最初是从丹参根中提取的抗菌和抗炎化合物。 隐丹参酮已被发现可抑制HIF的活化以及巨噬细胞迁移，对PI3K通路实现负调控。它对数种金黄色葡萄球菌菌株具有活性。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang
Li X, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(5), 1106-1112 (2007)
Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC
Shi Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(3), 481-486 (2005)
Zhengrong Mei et al.
Neurochemical research, 37(3), 622-628 (2011-11-22)
The deposition of amyloid β-protein (Aβ) fibrils into plaques within the brain parenchyma and along cerebral blood vessels is a hallmark of Alzheimer's disease (AD). Aβ42 oligomers and fibrils cause the breakdown of neural circuits, neuronal death and eventually dementia.
Hang Yu et al.
Archives of pharmacal research, 35(8), 1457-1464 (2012-09-04)
Cryptotanshinone, tanshinone I and tanshinone IIA are three major components in the extract of Salvia miltiorrhiza with pharmacological significance. However, their effective utilization is limited due to poor water solubility and bioavailability. Solid dispersion (SD) of the extract of Salvia
Won Sam Kim et al.
Biochemical and biophysical research communications, 425(2), 340-347 (2012-07-31)
Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells.
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