83700
罗丹宁
for spectrophotometric det. of gallic acid, ≥99.0%
别名:
2-硫代-4-噻唑烷酮
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关于此项目
经验公式（希尔记法）:
C3H3NOS2
化学文摘社编号:
分子量:
133.19
Beilstein:
110701
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.21
质量水平
方案
≥99.0% (HPLC)
≥99.0%
表单
crystals
质量
for spectrophotometric det. of gallic acid
技术
UV/Vis spectroscopy: suitable
mp
165-169 °C (lit.)
165-169 °C
溶解性
methanol: 0.5 g/10 mL, clear, colorless to greenish-yellow
SMILES字符串
O=C1CSC(=S)N1
InChI
1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
InChI key
KIWUVOGUEXMXSV-UHFFFAOYSA-N
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一般描述
Rhodanine is a drug, which prevents the multiplication of echovirus 12.
其他说明
用于重量分析测定银的试剂；用于没食子酸的分光光度测定
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Selective inhibition of uncoating of echovirus 12 by rhodanine A study on early virus-cell interactions
Eggers, Hans J
Virology, 78(1), 241-252 (1977)
Parminder Singh et al.
Biochemistry, 51(27), 5434-5442 (2012-06-19)
A perturbation of FtsZ assembly dynamics has been shown to inhibit bacterial cytokinesis. In this study, the antibacterial activity of 151 rhodanine compounds was assayed using Bacillus subtilis cells. Of 151 compounds, eight strongly inhibited bacterial proliferation at 2 μM.
Ming-Xia Song et al.
European journal of medicinal chemistry, 54, 403-412 (2012-06-19)
Five series of (Z)-5-(4-(2-oxo-2-phenylethoxy)benzylidene)-2-thioxothiazolidin-4-one derivatives (I-V) were synthesized, characterized, and evaluated for their anti-bacterial activity. Most of the synthesized compounds showed potent inhibition against several Gram-positive bacteria (including multidrug-resistant clinical isolates) with MIC values in the range of 1-32 μg/mL.
T Tomasić et al.
Current medicinal chemistry, 16(13), 1596-1629 (2009-05-16)
Rhodanines, thiazolidine-2,4-diones and pseudothiohydantoins have become a very interesting class of heterocyclic compounds since the introduction of various glitazones and epalrestat into clinical use for the treatment of type II diabetes mellitus and diabetic complications, respectively. Chemical modifications of these
Huan-qiu Li et al.
Bioorganic & medicinal chemistry, 20(14), 4194-4200 (2012-06-29)
A series of novel rhodanine-based acylsulfonamide derivatives were designed, synthesized, and evaluated as small-molecule inhibitors of anti-apoptotic Bcl-2 protein. These compounds exhibit potent antiproliferative activity in three human tumor cell lines (Hep G2, PC-3 and B16-F10). Among them, the most
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