83700
罗丹宁
for spectrophotometric det. of gallic acid, ≥99.0%
别名:
2-硫代-4-噻唑烷酮
质量水平
方案
≥99.0% (HPLC)
≥99.0%
表单
crystals
质量
for spectrophotometric det. of gallic acid
技术
UV/Vis spectroscopy: suitable
mp
165-169 °C (lit.)
165-169 °C
溶解性
methanol: 0.5 g/10 mL, clear, colorless to greenish-yellow
SMILES字符串
O=C1CSC(=S)N1
InChI
1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
InChI key
KIWUVOGUEXMXSV-UHFFFAOYSA-N
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一般描述
Rhodanine is a drug, which prevents the multiplication of echovirus 12.
其他说明
用于重量分析测定银的试剂；用于没食子酸的分光光度测定
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Selective inhibition of uncoating of echovirus 12 by rhodanine A study on early virus-cell interactions
Eggers, Hans J
Virology, 78(1), 241-252 (1977)
Huan-qiu Li et al.
Bioorganic & medicinal chemistry, 20(14), 4194-4200 (2012-06-29)
A series of novel rhodanine-based acylsulfonamide derivatives were designed, synthesized, and evaluated as small-molecule inhibitors of anti-apoptotic Bcl-2 protein. These compounds exhibit potent antiproliferative activity in three human tumor cell lines (Hep G2, PC-3 and B16-F10). Among them, the most
Tihomir Tomašić et al.
Expert opinion on drug discovery, 7(7), 549-560 (2012-05-23)
Rhodanine-based compounds have been associated with numerous biological activities. After many years of research in drug discovery, they have gained a reputation as being pan assay interference compounds (PAINS) and frequent hitters in screening campaigns. Rhodanine-based compounds are also aggregators
M. Thies et al.
Mikrochimica Acta, 809-809 (1973)
T Tomasić et al.
Current medicinal chemistry, 16(13), 1596-1629 (2009-05-16)
Rhodanines, thiazolidine-2,4-diones and pseudothiohydantoins have become a very interesting class of heterocyclic compounds since the introduction of various glitazones and epalrestat into clinical use for the treatment of type II diabetes mellitus and diabetic complications, respectively. Chemical modifications of these
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