89910
Withaferin A
analytical standard
别名:
4β,5β,6β,22R)-5,6-环氧-4,22,27-三羟基-1-氧-麦角甾烷-2,24-二烯-26-油酸 δ-内酯, Withaferine
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关于此项目
经验公式（希尔记法）:
C28H38O6
化学文摘社编号:
分子量:
470.60
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
MDL number:
grade
analytical standard
Quality Level
assay
≥95.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
food and beverages
format
neat
storage temp.
2-8°C
SMILES string
C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C
InChI
1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
InChI key
DBRXOUCRJQVYJQ-CKNDUULBSA-N
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Application
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Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Other Notes
这种化合物常见于以下属的植物中：印度醉茄
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
438.8 °F
flash_point_c
226 °C
S Kushwaha et al.
Parasite immunology, 34(4), 199-209 (2012-03-08)
Withania somnifera is an ayurvedic Indian medicinal plant whose immunomodulatory activities have been widely used as a home remedy for several ailments. We recently observed immunostimulatory properties in the root extracts of chemotypes NMITLI-101, NMITLI-118, NMITLI-128 and pure withanolide, withaferin
Abhinav Grover et al.
BMC genomics, 13 Suppl 7, S20-S20 (2013-01-11)
Leishmaniasis is caused by several species of leishmania protozoan and is one of the major vector-born diseases after malaria and sleeping sickness. Toxicity of available drugs and drug resistance development by protozoa in recent years has made Leishmaniasis cure difficult
Stephanie M Cohen et al.
American journal of surgery, 204(6), 895-900 (2012-12-13)
Sorafenib (SO), a multikinase-targeted inhibitor in clinical trials for papillary and anaplastic cancers, shows limited efficacy with moderate toxicity. Withaferin A (WA), a natural withanolide, shows potent preclinical anticancer activity in thyroid cancers through multiple cytotoxic mechanisms including heat-shock protein
Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells.
Hee Jung Um et al.
Biochemical and biophysical research communications, 427(1), 24-29 (2012-09-18)
Withaferin A, the active component of Withania somnifera, causes cytotoxicity in a variety of tumor cell lines. In this study, we show that withaferin A inhibits constitutive and IL-6-induced phosphorylation of STAT3 (on Tyr705), but not IFN-γ-induced STAT1 phosphorylation. Withaferin
Boris Grin et al.
PloS one, 7(6), e39065-e39065 (2012-06-22)
Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 89910-10MG | 04061833238578 |
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