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Merck
CN

90221

瑞替加滨

analytical standard

别名:

D-23129, N-（2-氨基-4-（4-氟苄基氨基）苯基）氨基甲酸乙酯, 依佐加滨

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关于此项目

经验公式（希尔记法）:
C16H18FN3O2
化学文摘社编号:
150812-12-7
分子量:
303.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329769861
MDL number:
MFCD04307735
Beilstein/REAXYS Number:
8072099

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产品名称

瑞替加滨, analytical standard

InChI

1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)

InChI key

PCOBBVZJEWWZFR-UHFFFAOYSA-N

SMILES string

FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

drug control

USDEA Schedule IV

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤1.0% water (calc. from elemental analysis)

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479)

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相关类别

Application

瑞替加滨可用作参考标准品，用于通过高效液相色谱结合串联质谱和正离子大气压化学电离（HPLC-APCI-MS/MS）测定生物基质中的瑞替加滨。

Biochem/physiol Actions

瑞替加滨是一种 Kv7.2-7.5 钾通道激活剂； 抗惊厥药。
瑞替加滨（依佐加滨）是一种具有抗惊厥活性的 Kv7.2-7.5 （KCNQ2-5）神经元钾通道开放剂。

General description

瑞替加滨是一种抗癫痫药物，它通过诱导稳态激活的大型超极化转变（hyperpolarizing shift）来激活神经元 KCNQ 型 K+ 通道。

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM7336
BCCJ0275
BCCF5642
BCBZ5459
BCBR7183V

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Wuttke VT, et al.
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Determination of retigabine and its acetyl metabolite in biological matrices by on-line solid-phase extraction (column switching) liquid chromatography with tandem mass spectrometry.
Knebel GN, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 748(1), 97-111 (2000)
Identification, characterization, synthesis and HPLC quantification of new process-related impurities and degradation products in retigabine.
Dousa M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 94, 71-76 (2014)
Lyubov I Brueggemann et al.
Molecular pharmacology, 86(3), 330-341 (2014-06-20)
Recent research suggests that smooth muscle cells express Kv7.4 and Kv7.5 voltage-activated potassium channels, which contribute to maintenance of their resting membrane voltage. New pharmacologic activators of Kv7 channels, ML213 (N-mesitybicyclo[2.2.1]heptane-2-carboxamide) and ICA-069673 N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide), have been reported to discriminate among

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