916587
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid
≥95%
别名:
Semi-flexible linker for PROTAC® development
form
powder
InChI key
PDPYHAXCPUSEMT-UHFFFAOYSA-N
InChI
1S/C17H23NO4/c1-17(2,3)22-16(21)18-9-7-12(8-10-18)13-5-4-6-14(11-13)15(19)20/h4-6,11-12H,7-10H2,1-3H3,(H,19,20)
SMILES string
O=C(OC(C)(C)C)N1CCC(C2=CC(C(O)=O)=CC=C2)CC1
assay
≥95%
reaction suitability
reagent type: linker
functional group
Boc, carboxylic acid
storage temp.
2-8°C
Quality Level
Application
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Haifeng Tang et al.
Bioorganic & medicinal chemistry letters, 20(20), 6088-6092 (2010-09-14)
A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in
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