916870
4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid
≥95%
别名:
Semi-flexible linker for PROTAC® development
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关于此项目
Assay:
≥95%
Form:
powder
Quality Segment
assay
≥95%
form
powder
reaction suitability
reagent type: linker
technique(s)
targeted protein degradation: suitable
functional group
Boc, carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(N(CC1)CCC1C(C=C2)=CC=C2C(O)=O)OC(C)(C)C
InChI
1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-13(9-11-18)12-4-6-14(7-5-12)15(19)20/h4-7,13H,8-11H2,1-3H3,(H,19,20)
InChI key
YCNVQGGUCDVTIZ-UHFFFAOYSA-N
Application
4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
警示词
Warning
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable