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Merck
CN

917893

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

别名:

Semi-flexible linker for PROTAC® development

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关于此项目

经验公式(希尔记法):
C12H18ClNO
化学文摘社编号:
分子量:
227.73
UNSPSC Code:
12352116
MDL number:
Assay:
≥95%
Form:
powder
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Quality Level

assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

hydroxyl

storage temp.

2-8°C

SMILES string

OCC1=C(C2CCNCC2)C=CC=C1.Cl

Application

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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全球贸易项目编号

货号GTIN
917893-100MG04061842601981