917915
2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid
≥95%
别名:
Semi-flexible linker for PROTAC® development
产品名称
2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid, ≥95%
SMILES string
O=C(N(CC1)CCC1C2=C(CC(O)=O)C=CC=C2)OC(C)(C)C
assay
≥95%
form
powder
reaction suitability
reagent type: linker
functional group
Boc
carboxylic acid
storage temp.
2-8°C
Quality Level
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Application
2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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