91990
3,3′,5-三碘代-L-甲状腺原氨酸
≥97.0% (sum of enantiomers, HPLC)
别名:
O-(4-羟基-3-碘苯基)-3,5-二碘代-L-酪氨酸, T3, 碘噻罗宁
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关于此项目
经验公式（希尔记法）:
C15H12I3NO4
化学文摘社编号:
分子量:
650.97
EC Number:
229-999-3
UNSPSC Code:
51111800
MDL number:
Beilstein/REAXYS Number:
2710227
InChI
1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChI key
AUYYCJSJGJYCDS-LBPRGKRZSA-N
SMILES string
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
assay
≥97.0% (sum of enantiomers, HPLC)
optical activity
[α]20/D +25±2°, c = 1% in ethanol/1 M HCl (2:1)
impurities
≤2% 3,5-diiodo thyronine, ≤2% thyroxine
mp
232-240 °C (dec.), 234-238 °C (lit.)
storage temp.
2-8°C
Other Notes
Review: Thyroid hormone action at the nuclear level
signalword
Danger
hcodes
Hazard Classifications
STOT RE 1
target_organs
Thyroid,Cardio-vascular system,Kidney
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
J H Oppenheimer
Annals of internal medicine, 102(3), 374-384 (1985-03-01)
Recent findings have led to a greater understanding of thyroid hormone action. The nuclear receptor for triiodothyronine is an integral component of a larger chromatin fragment. A stereospecific energy-dependent transport system appears responsible for translocation of triiodothyronine from cytosol to
R Calvo et al.
The Journal of clinical investigation, 86(3), 889-899 (1990-09-01)
To study the protective effects of maternal thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in congenital hypothyroidism, we gave pregnant rats methimazole (MMI), an antithyroid drug that crosses the placenta, and infused them with three different doses of T4 or T3. The
T Zimmermann-Belsing et al.
Clinical endocrinology, 49(5), 589-595 (1999-04-10)
Previous studies of leptin in thyrotoxic human subjects have been short-term and cross-sectional. We have measured serum leptin concentrations in thyrotoxic patients in order to study the influence of endogenous thyroid hormones on the relationship between serum leptin and fat
Mark D Erion et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(39), 15490-15495 (2007-09-20)
Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and anti-obesity agents remains largely unexplored in humans because of dose-limiting cardiac effects and effects on the thyroid hormone axis (THA), muscle metabolism, and
H Mizuma et al.
Circulation research, 88(3), 313-318 (2001-02-17)
Thyroid hormone has been reported to have significant effects on the peripheral vascular system, including relaxation of vascular smooth muscle cells and antiatherosclerotic effects. To exert its biological activity, thyroxine, which is a major secretory product of thyroid gland, needs
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