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Merck
CN

92822

Sigma-Aldrich

苦基磺酸 溶液

1 M in H2O

别名:

2,4,6-三硝基苯磺酸 溶液, TNBS

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关于此项目

经验公式（希尔记法）:
C6H3N3O9S
化学文摘社编号:
2508-19-2
分子量:
293.17
Beilstein:
572358
MDL编号:
MFCD00064382
UNSPSC代码:
12352005
PubChem化学物质编号:
329770176
NACRES:
NA.25

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表单

liquid

质量水平

200

浓度

1 M in H2O

密度

1.14 g/mL at 20 °C

ε (消光系数)

≤0.85 at 340 nm

运输

dry ice

储存温度

−20°C

SMILES字符串

OS(=O)(=O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O

InChI

1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)

InChI key

NHJVRSWLHSJWIN-UHFFFAOYSA-N

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应用

亲水改性剂。 具有氨基化合物的衍生物可以通过肼进行再生。
苦味磺酸（2,4,6-三硝基苯磺酸溶液，TNBS）可用于研究细胞内pH的调节机制。 TNBS可用于诱发炎症性肠病（IBD）/结肠炎，从而用于其机理和治疗方法的研究。

其他说明

销售限制可能适用

免责声明

在≥0°C下保存时会发生降解，并形成沉淀（苦味酸）

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Desen. Expl. 3 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

3 - Flammable liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
CDBG1451
BCCJ6010
CDBG2723
BCCF0608
CDBF6027

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Ana Beatriz Albino de Almeida et al.
Journal of ethnopharmacology, 146(1), 300-310 (2013-01-15)
In Brazilian traditional medicine, Arctium lappa (Asteraceae), has been reported to relieve gastrointestinal symptoms. In the present study, we investigated the effects of the lactone sesquiterpene onopordopicrin enriched fraction (ONP fraction) from Arctium lappa in an experimental colitis model induced
Joel Castro et al.
Gastroenterology, 145(6), 1334-1346 (2013-08-21)
Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about the mechanism by which linaclotide reduces abdominal pain in patients with IBS-C. We
Bas Kremer et al.
PloS one, 7(11), e50388-e50388 (2012-12-12)
The recurrent TNBS-colitis model in BALB/c mice has been proposed as a model of Inflammatory Bowel Disease with a shifting pattern of local cytokines with the expression of Th1 cytokines during the early phase, Th17 cytokines during the intermediate phase
Zhen Huang et al.
Gut, 63(8), 1247-1257 (2013-09-04)
Emerging evidence suggests that microRNA (miRNA)-mediated gene regulation influences a variety of autoimmune disease processes, including Crohn's disease (CD), but the biological function of miRNAs in CD remains unclear. We examine miRNA level in colon tissues and study the potential
A Arranz et al.
Journal of controlled release : official journal of the Controlled Release Society, 165(3), 163-172 (2012-11-28)
CD40-CD40L interactions appear to play an important role in the pathogenesis of experimental colitis. We tested the effect and investigated the underlying mechanism of action of systemically administered antisense oligonucleotide (ASO) targeting CD40 formulated in amphoteric liposomes (nov038/CD40). The charge
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