92822
苦基磺酸 溶液
1 M in H2O
别名:
2,4,6-三硝基苯磺酸 溶液, TNBS
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关于此项目
经验公式（希尔记法）:
C6H3N3O9S
化学文摘社编号:
分子量:
293.17
UNSPSC Code:
12352005
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
572358
产品名称
苦基磺酸 溶液, 1 M in H2O
InChI
1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)
SMILES string
OS(=O)(=O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
InChI key
NHJVRSWLHSJWIN-UHFFFAOYSA-N
form
liquid
concentration
1 M in H2O
Quality Level
solubility
water: soluble at 20 °C
density
1.14 g/mL at 20 °C
ε (extinction coefficient)
≤0.85 at 340 nm
shipped in
dry ice
storage temp.
−20°C
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Application
亲水改性剂。 具有氨基化合物的衍生物可以通过肼进行再生。
苦味磺酸（2,4,6-三硝基苯磺酸溶液，TNBS）可用于研究细胞内pH的调节机制。 TNBS可用于诱发炎症性肠病（IBD）/结肠炎，从而用于其机理和治疗方法的研究。
Disclaimer
在≥0°C下保存时会发生降解，并形成沉淀（苦味酸）
Other Notes
销售限制可能适用
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Desen. Expl. 3 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
此项目有
Joel Castro et al.
Gastroenterology, 145(6), 1334-1346 (2013-08-21)
Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about the mechanism by which linaclotide reduces abdominal pain in patients with IBS-C. We
Ana Beatriz Albino de Almeida et al.
Journal of ethnopharmacology, 146(1), 300-310 (2013-01-15)
In Brazilian traditional medicine, Arctium lappa (Asteraceae), has been reported to relieve gastrointestinal symptoms. In the present study, we investigated the effects of the lactone sesquiterpene onopordopicrin enriched fraction (ONP fraction) from Arctium lappa in an experimental colitis model induced
Øystein Brenna et al.
PloS one, 8(1), e54543-e54543 (2013-02-06)
Rectal instillation of trinitrobenzene sulphonic acid (TNBS) in ethanol is an established model for inflammatory bowel disease (IBD). We aimed to 1) set up a TNBS-colitis protocol resulting in an endoscopic and histologic picture resembling IBD, 2) study the correlation
Carla Petrella et al.
Pharmacological research, 70(1), 72-79 (2013-01-29)
Nociceptin/orphanin FQ (N/OFQ) and nociceptin orphanin peptide (NOP) receptors represent an endogenous system modulating gastrointestinal functions and inflammation. We investigated the peripheral effect of N/OFQ and of UFP-101, the NOP antagonist, in a model of colitis induced by TNBS (2,4,6
Bas Kremer et al.
PloS one, 7(11), e50388-e50388 (2012-12-12)
The recurrent TNBS-colitis model in BALB/c mice has been proposed as a model of Inflammatory Bowel Disease with a shifting pattern of local cytokines with the expression of Th1 cytokines during the early phase, Th17 cytokines during the intermediate phase
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