938750
GPhos ChemBeads
solid
别名:
(3-(tert-Butoxy)-2′,6′-diisopropyl-6-methoxy-[1,1′-biphenyl]-2-yl)dicyclohexylphosphane ChemBeads
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关于此项目
经验公式（希尔记法）:
C35H53O2P
化学文摘社编号:
分子量:
536.77
UNSPSC Code:
12352100
MDL number:
NACRES:
NA.21
产品名称
GPhos ChemBeads,
InChI key
JKLUIDIKASJZCK-UHFFFAOYSA-N
SMILES string
CC(C(C=CC=C1C(C)C)=C1C2=C(OC)C=CC(OC(C)(C)C)=C2P(C3CCCCC3)C4CCCCC4)C
InChI
1S/C35H53O2P/c1-24(2)28-20-15-21-29(25(3)4)32(28)33-30(36-8)22-23-31(37-35(5,6)7)34(33)38(26-16-11-9-12-17-26)27-18-13-10-14-19-27/h15,20-27H,9-14,16-19H2,1-8H3
Quality Level
product line
ChemBeads
form
solid
composition
loading of catalyst, 4-6 wt. %
reaction suitability
reaction type: Cross Couplings
reagent type: catalyst
reagent type: ligand
mp
230-233 °C
functional group
phosphine
Application
GPhos is a dialkylbiaryl monophosphine ligand developed by the Buchwald group for aryl amination reactions. The GPhos Pd oxidative addition complex (OAC) enables room temperature C-N couplings with complex substrates at higher efficiency than previously developed ligands.
Learn more about Buchwald Phosphine Ligands
For general uses, product is also available in powdered form (918008)
Learn more about Buchwald Phosphine Ligands
For general uses, product is also available in powdered form (918008)
Features and Benefits
ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
General description
GPhos is a Buchwald-type ligand used in various cross-coupling reactions.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Noah P Tu et al.
Angewandte Chemie (International ed. in English), 58(24), 7987-7991 (2019-03-21)
Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents
Ana L Aguirre et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 27(51), 12981-12986 (2021-07-08)
High-throughput experimentation (HTE) methods are central to modern medicinal chemistry. While many HTE approaches to C-N and Csp2 -Csp2 bonds are available, options for Csp2 -Csp3 bonds are limited. We report here how the adaptation of nickel-catalyzed cross-electrophile coupling of
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