A115
阿米替林代谢物，(±)-E-10-羟基化-
analytical standard
别名:
(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[a,d]环庚烯-10-醇
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关于此项目
经验公式（希尔记法）:
C20H23NO
化学文摘社编号:
分子量:
293.40
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
表单
solid
技术
HPLC: suitable
gas chromatography (GC): suitable
颜色
white
mp
97-99 °C
溶解性
0.1 M HCl: soluble
H2O: insoluble
methanol: soluble
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13
InChI
1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+
InChI key
GHWBJXOKAFHZAI-SFQUDFHCSA-N
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应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
阿米替林代谢物，三环抗抑郁剂；色谱标准品。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
B Mellström et al.
Drug metabolism and disposition: the biological fate of chemicals, 9(6), 565-568 (1981-11-01)
The rates of demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline by microsomes from adult human livers were determined by use of mass-fragmentographic or liquid-chromatographic quantitation of the formed metabolites. The demethylation rates of amitriptyline and 10-hydroxyamitriptyline were higher than
X H Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 28(2), 85-91 (1993-01-01)
The demethylation and hydroxylation of amitriptyline were calculated from the ratios between the area under concentration--time curve (AUC) of amitriptyline and its three metabolites in eight healthy Chinese volunteers after a single oral dose of 100 mg amitriptyline. Great interindividual
Determination of tricyclic antidepressants in body fluids and organ material by HPLC.
Wedy, et al.
Fresenius Journal of Analytical Chemistry, 332, 266-266 (1988)
R T Coutts et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(1), 33-47 (1997-01-01)
1. Expressed human cytochrome P450 enzyme CPY2D6 was used to metabolize amitriptyline (AMI). It was established that CYP2D6 not only catalyzed ring 10-hydroxylation of AMI, but also mediated its N-demethylation to nortriptyline (NT), as well as the formation of 10-hydroxy-NT
E Nusser et al.
Journal of chromatography, 528(1), 163-171 (1990-06-08)
E- and Z-10-hydroxyamitriptyline (E- and Z-10-OH-AT) are racemic alcoholic metabolites of the antidepressant amitriptyline. Their enantiomers were separated by high-performance liquid chromatography as diastereomeric derivatives using R-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (Mosher's reagent). Although E-10-hydroxyamitriptyline excreted in patient urine in free form or
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