grade
analytical standard
Quality Level
assay
≥98% (HPLC)
form
solid
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
solubility
DMSO: ~45 mg/mL, H2O: insoluble
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2
InChI
1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
InChI key
VGZSUPCWNCWDAN-UHFFFAOYSA-N
Gene Information
human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)
Application
Acetohexamide may be used as a reference standard for the determination of acetohexamide in presence of 1-methylnicotinamide reagent in plasma sample and tablet formulations by spectrofluorimetry method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
口服降血糖药
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Y Imamura et al.
Journal of biochemistry, 121(4), 705-710 (1997-04-01)
The structural requirements of acetohexamide reductases purified from rabbit liver, kidney, and heart for substrates and inhibitors were examined. Acetohexamide, an oral antidiabetic drug with a ketone group, and analogs of it with various alkyl groups instead of the cyclohexyl
Hibah Aldawsari et al.
International journal of pharmaceutics, 453(2), 315-321 (2013-06-26)
A new polymorph of acetohexamide (Form VI) was prepared via the formation of a complex with 2-hydoxybutyl-β-cyclodextrin (HB-β-CD) in aqueous solution. An alkaline solution of acetohexamide and HB-β-CD was adjusted to pH 4.0 by titration with hydrochloric acid. The resulting
Y Imamura et al.
Journal of biochemistry, 119(4), 648-652 (1996-04-01)
An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme was estimated to be 110 kDa by gel filtration
Zenghan Tong et al.
Journal of chromatography. A, 1218(49), 8915-8924 (2011-05-27)
This study examined the use of frontal analysis and high-performance affinity chromatography for detecting heterogeneous binding in biomolecular interactions, using the binding of acetohexamide with human serum albumin (HSA) as a model. It was found through the use of this
Fluorimetric determination of acetohexamide in plasma and tablet formulations using 1-methylnicotinamide.
Girgis-Takla P and Chroneos I
Analyst, 104(1235), 117-123 (1979)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A178-1G | 04061826033852 |
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