A178
醋磺己脲
analytical standard, ≥98% (HPLC)
别名:
4-乙酰基-N-[(环己胺基)羰基]苯磺酰胺
等级
analytical standard
质量水平
方案
≥98% (HPLC)
表单
solid
技术
HPLC: suitable
gas chromatography (GC): suitable
颜色
white
溶解性
DMSO: ~45 mg/mL
H2O: insoluble
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2
InChI
1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
InChI key
VGZSUPCWNCWDAN-UHFFFAOYSA-N
基因信息
human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)
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应用
Acetohexamide may be used as a reference standard for the determination of acetohexamide in presence of 1-methylnicotinamide reagent in plasma sample and tablet formulations by spectrofluorimetry method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
口服降血糖药
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Zenghan Tong et al.
Journal of chromatography. A, 1218(49), 8915-8924 (2011-05-27)
This study examined the use of frontal analysis and high-performance affinity chromatography for detecting heterogeneous binding in biomolecular interactions, using the binding of acetohexamide with human serum albumin (HSA) as a model. It was found through the use of this
Y Imamura et al.
Journal of biochemistry, 119(4), 648-652 (1996-04-01)
An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme was estimated to be 110 kDa by gel filtration
Yorishige Imamura et al.
Journal of applied toxicology : JAT, 24(6), 437-441 (2004-11-24)
This study was designed to elucidate strain- and sex-related differences of carbonyl reductase activity in rat kidney by using the oral antidiabetic drug acetohexamide as substrate. The frequency distribution of carbonyl reductase activities in kidney microsomes of male Fischer 344
G A Stephenson
Journal of pharmaceutical sciences, 89(7), 958-966 (2000-06-22)
Recent advances in crystallographic computing have made it possible to solve by powder diffraction methods structures that have not been possible to solve by single-crystal methods. Although there is vast improvement in the quality of data obtained from high-intensity synchrotron
K Seri et al.
European journal of pharmacology, 389(2-3), 253-256 (2000-02-26)
We investigated the mechanism of the hypoglycemic effect of (R)-4-(1-acetoxyethyl)-N-(cyclohexylcarbamoyl)benzene-sulfonamide [(R)-acetoxyhexamide; (R)-ACX], a new sulfonylurea compound. (R)-ACX potently stimulated the release of insulin from cultured pancreatic beta-cells (HIT T15 cells), established from hamster islet cells SV40-transformed. When (R)-ACX was orally
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