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Merck
CN

A178

Supelco

醋磺己脲

analytical standard, ≥98% (HPLC)

别名:

4-乙酰基-N-[(环己胺基)羰基]苯磺酰胺

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关于此项目

经验公式(希尔记法):
C15H20N2O4S
化学文摘社编号:
分子量:
324.40
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
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等级

analytical standard

质量水平

方案

≥98% (HPLC)

表单

solid

技术

HPLC: suitable
gas chromatography (GC): suitable

颜色

white

溶解性

DMSO: ~45 mg/mL
H2O: insoluble

应用

forensics and toxicology
pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2

InChI

1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

InChI key

VGZSUPCWNCWDAN-UHFFFAOYSA-N

基因信息

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应用

Acetohexamide may be used as a reference standard for the determination of acetohexamide in presence of 1-methylnicotinamide reagent in plasma sample and tablet formulations by spectrofluorimetry method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化/生理作用

口服降血糖药

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Y Imamura et al.
Journal of biochemistry, 119(4), 648-652 (1996-04-01)
An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme was estimated to be 110 kDa by gel filtration
Zenghan Tong et al.
Journal of chromatography. A, 1218(49), 8915-8924 (2011-05-27)
This study examined the use of frontal analysis and high-performance affinity chromatography for detecting heterogeneous binding in biomolecular interactions, using the binding of acetohexamide with human serum albumin (HSA) as a model. It was found through the use of this
Yorishige Imamura et al.
Journal of applied toxicology : JAT, 24(6), 437-441 (2004-11-24)
This study was designed to elucidate strain- and sex-related differences of carbonyl reductase activity in rat kidney by using the oral antidiabetic drug acetohexamide as substrate. The frequency distribution of carbonyl reductase activities in kidney microsomes of male Fischer 344
Fluorimetric determination of acetohexamide in plasma and tablet formulations using 1-methylnicotinamide.
Girgis-Takla P and Chroneos I
Analyst, 104(1235), 117-123 (1979)
Hibah Aldawsari et al.
International journal of pharmaceutics, 453(2), 315-321 (2013-06-26)
A new polymorph of acetohexamide (Form VI) was prepared via the formation of a complex with 2-hydoxybutyl-β-cyclodextrin (HB-β-CD) in aqueous solution. An alkaline solution of acetohexamide and HB-β-CD was adjusted to pH 4.0 by titration with hydrochloric acid. The resulting

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