A178
醋磺己脲
analytical standard, ≥98% (HPLC)
别名:
4-乙酰基-N-[(环己胺基)羰基]苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C15H20N2O4S
化学文摘社编号:
分子量:
324.40
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
213-530-4
MDL number:
InChI key
VGZSUPCWNCWDAN-UHFFFAOYSA-N
InChI
1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
SMILES string
CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2
grade
analytical standard
assay
≥98% (HPLC)
form
solid
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
solubility
DMSO: ~45 mg/mL, H2O: insoluble
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Gene Information
human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)
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Application
Acetohexamide may be used as a reference standard for the determination of acetohexamide in presence of 1-methylnicotinamide reagent in plasma sample and tablet formulations by spectrofluorimetry method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
口服降血糖药
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Y Imamura et al.
Journal of biochemistry, 121(4), 705-710 (1997-04-01)
The structural requirements of acetohexamide reductases purified from rabbit liver, kidney, and heart for substrates and inhibitors were examined. Acetohexamide, an oral antidiabetic drug with a ketone group, and analogs of it with various alkyl groups instead of the cyclohexyl
Hibah Aldawsari et al.
International journal of pharmaceutics, 453(2), 315-321 (2013-06-26)
A new polymorph of acetohexamide (Form VI) was prepared via the formation of a complex with 2-hydoxybutyl-β-cyclodextrin (HB-β-CD) in aqueous solution. An alkaline solution of acetohexamide and HB-β-CD was adjusted to pH 4.0 by titration with hydrochloric acid. The resulting
Hideaki Shimada et al.
Archives of toxicology, 76(1), 8-12 (2002-03-05)
Administration of cadmium (Cd) at a dose of 1.23 mg/kg (2.0 mg/kg as CdCl(2)) markedly decreased the activity of an enzyme (acetohexamide reductase) catalysing the ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of male rats. However, the
H Koyama et al.
Biopharmaceutics & drug disposition, 18(9), 791-801 (1998-01-16)
The binding properties of hypoglycaemic drugs to glycosylated human serum albumin (G-HSA) were investigated using a fluorescence quenching method. Displacement patterns between tolbutamide and Sudlow's-site-specific drugs to G-HSA were also investigated. The order of the binding affinities of these drugs
Y Imamura et al.
Journal of biochemistry, 119(4), 648-652 (1996-04-01)
An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme was estimated to be 110 kDa by gel filtration
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