A178
醋磺己脲
analytical standard, ≥98% (HPLC)
别名:
4-乙酰基-N-[(环己胺基)羰基]苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C15H20N2O4S
化学文摘社编号:
分子量:
324.40
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
213-530-4
MDL number:
InChI key
VGZSUPCWNCWDAN-UHFFFAOYSA-N
InChI
1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
SMILES string
CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2
grade
analytical standard
assay
≥98% (HPLC)
form
solid
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
solubility
DMSO: ~45 mg/mL, H2O: insoluble
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Gene Information
human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)
Application
Acetohexamide may be used as a reference standard for the determination of acetohexamide in presence of 1-methylnicotinamide reagent in plasma sample and tablet formulations by spectrofluorimetry method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
口服降血糖药
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Y Imamura et al.
Journal of biochemistry, 119(4), 648-652 (1996-04-01)
An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme was estimated to be 110 kDa by gel filtration
Fluorimetric determination of acetohexamide in plasma and tablet formulations using 1-methylnicotinamide.
Girgis-Takla P and Chroneos I
Analyst, 104(1235), 117-123 (1979)
Zenghan Tong et al.
Journal of chromatography. A, 1218(49), 8915-8924 (2011-05-27)
This study examined the use of frontal analysis and high-performance affinity chromatography for detecting heterogeneous binding in biomolecular interactions, using the binding of acetohexamide with human serum albumin (HSA) as a model. It was found through the use of this
Yorishige Imamura et al.
Journal of applied toxicology : JAT, 24(6), 437-441 (2004-11-24)
This study was designed to elucidate strain- and sex-related differences of carbonyl reductase activity in rat kidney by using the oral antidiabetic drug acetohexamide as substrate. The frequency distribution of carbonyl reductase activities in kidney microsomes of male Fischer 344
G A Stephenson
Journal of pharmaceutical sciences, 89(7), 958-966 (2000-06-22)
Recent advances in crystallographic computing have made it possible to solve by powder diffraction methods structures that have not been possible to solve by single-crystal methods. Although there is vast improvement in the quality of data obtained from high-intensity synchrotron
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