A3766
安他唑啉 磷酸盐
analytical standard, for drug analysis
别名:
2-(N-苄基苯胺基甲基)-2-咪唑啉
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关于此项目
线性分子式:
C17H19N3 · H3PO4
化学文摘社编号:
分子量:
363.35
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
205-831-4
MDL number:
Quality Level
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
OP(O)(O)=O.C1CN=C(CN(Cc2ccccc2)c3ccccc3)N1
InChI
1S/C17H19N3.H3O4P/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;1-5(2,3)4/h1-10H,11-14H2,(H,18,19);(H3,1,2,3,4)
InChI key
DUIGUKRYYAGJAF-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
咪唑啉激动剂；诱导 β 细胞释放胰岛素比依法克生更有效；H1 组胺受体拮抗剂
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
D Berdeu et al.
European journal of pharmacology, 324(2-3), 233-239 (1997-04-18)
In vivo effects of an imidazoline devoid of alpha2-adrenoceptor antagonistic properties, antazoline, on insulin secretion and glycemia were investigated both in fasted rats and dogs. In both species, antazoline (1.5 mg/kg i.v.) transiently increased insulinemia without affecting basal plasma glucose
D Berdeu et al.
European journal of pharmacology, 275(1), 91-98 (1995-02-24)
The relative potencies of imidazoline compounds to induce insulin secretion and vascular resistance were compared in the isolated perfused rat pancreas. On insulin secretion, only the two imidazolines, antazoline and efaroxan, induced a concentration-dependent response, antazoline being 10 times more
R Wertheimer et al.
Klinische Monatsblatter fur Augenheilkunde, 210(2), 93-96 (1997-02-01)
Allergic conjunctivitis is one of the most frequent allergic diseases of the anterior eye segment. This multicentre, clinical trial was an investigation to compare the antiallergic efficacy, local tolerance and safety of Antazolin/Tetryzolin eye drops and Levocabastine eye drops. 69
D Berdeu et al.
European journal of pharmacology, 254(1-2), 119-125 (1994-03-11)
The effects of imidazolines and derivatives were studied on insulin secretion and vascular resistance in the isolated perfused rat pancreas. On insulin secretion, two imidazoline alpha 2-adrenoceptor antagonists, efaroxan (1-100 microM) and RX821002 (10 microM), had a stimulating response; however
M Mourtada et al.
Naunyn-Schmiedeberg's archives of pharmacology, 361(2), 146-154 (2000-02-24)
Pancreatic beta-cells express imidazoline binding sites which play a role in the regulation of insulin secretion, but it is not known whether ligands for these sites also affect other aspects of beta-cell physiology. In the present study, we have investigated
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