A5000
对乙酰氨基酚
meets USP testing specifications, 98.0-102.0%, powder
别名:
4′-羟基乙酰苯胺, 4-乙酰氨基酚, N-(4-羟基苯基)乙酰胺, N-乙酰基-4-氨基苯酚, APAP, 扑热息痛
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线性分子式:
CH3CONHC6H4OH
化学文摘社编号:
分子量:
151.16
UNSPSC Code:
12352111
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2208089
产品名称
对乙酰氨基酚, meets USP testing specifications, 98.0-102.0%, powder
InChI
1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
SMILES string
CC(=O)Nc1ccc(O)cc1
InChI key
RZVAJINKPMORJF-UHFFFAOYSA-N
agency
USP/NF
meets USP testing specifications
assay
98.0-102.0%
form
powder
mp
168-172 °C (lit.)
solubility
DMSO: 5 M
ethanol: 50 mg/mL
H2O: very slightly soluble
application(s)
pharmaceutical (small molecule)
Quality Level
Gene Information
human ... FAAH(2166), PTGS1(5742), PTGS2(5743), TRPV1(7442)
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Application
镇痛剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
364.3 °F - Pensky-Martens closed cup
flash_point_c
184.6 °C - Pensky-Martens closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Mohammad A Rahman et al.
Scientific reports, 9(1), 6571-6571 (2019-04-27)
Cellular CYP2E1 is well-known to mediate alcohol- (ALC) and acetaminophen- (APAP) induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining importance in understanding mechanism of intra- and inter-cellular communication, the functional role of drug metabolizing cytochrome P450
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
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