A9797
盐酸氨溴索 盐酸盐
analytical standard
别名:
2-氨基-3,5-二溴-N-（ 反式 -4-羟基环己基）苄胺
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关于此项目
经验公式（希尔记法）:
C13H18Br2N2O · HCl
化学文摘社编号:
分子量:
414.56
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
245-899-2
MDL number:
InChI key
QNVKOSLOVOTXKF-PFWPSKEQSA-N
InChI
1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;
SMILES string
Cl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2
grade
analytical standard
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
2-8°C
Quality Level
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General description
盐酸氨溴索为粘液溶解祛痰药，是溴己新的代谢产物。 用于治疗以黏稠或黏液过多时为特征的呼吸障碍。
Application
在使用反相顺序注射色谱法 (RP-SIC) 和反相高效液相色谱法 (RP-HPLC) 测定药物制剂中盐酸氨溴索含量时，盐酸氨溴索标准品可用作参比标准品。
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Biochem/physiol Actions
溴己新代谢物。
钠通道 Nav1.8 阻断剂
钠通道 Nav1.8 阻断剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Wolfram Gaida et al.
Neuropharmacology, 49(8), 1220-1227 (2005-09-27)
Neuropathic pain affects many patients, and treatment today is far from being perfect. Nav1.8 Na(+) channels, which are expressed by small fibre sensory neurons, are promising targets for novel analgesics. Na(+) channel blockers used today, however, show only limited selectivity
Jauch, R., et al.
Arzneimittelforschung, 13, 474-474 (1963)
Concise Dictionary of Pharmacological Agents: Properties and Synonyms (2012)
Sequential injection chromatographic determination of ambroxol hydrochloride and doxycycline in pharmaceutical preparations.
Satinsky D, et al.
Talanta, 68(2), 214-218 (2005)
Giovanni Ciana et al.
Molecular genetics and metabolism reports, 25, 100678-100678 (2020-12-10)
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase encoding gene (GBA1), resulting in the deficient activity of acid β-glucosidase (GCase). To date, there is no approved treatment for the neurological manifestations
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