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Merck
CN

B1141000

硫酸博来霉素

European Pharmacopoeia (EP) Reference Standard

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关于此项目

化学文摘社编号:
9041-93-4
MDL number:
MFCD00070310
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

硫酸博来霉素, European Pharmacopoeia (EP) Reference Standard

SMILES string

[S+](CCCNC(=O)c1nc([s]c1)c2nc([s]c2)CCNC(=O)C(NC(=O)C(C(O)C(NC(=O)C(NC(=O)c6nc(nc(c6C)N)C(NCC(N)C(=O)N)CC(=O)N)C(O[C@@H]4O[C@H]([C@H]([C@@H]([C@@H]4O[C@H]5O[C@@H]([C@H]([C@@H]([C@@H]5O)O\C(=N\[H])\[O-])O)CO)O)O)CO)c3[nH]cnc3)C)C)C(O)C)(C)C.[S](=O)(=O)(O)O

InChI

1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1

InChI key

WUIABRMSWOKTOF-OCBSMOPSSA-N

grade

pharmaceutical primary standard

API family

bleomycin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

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相关类别

Application

Bleomycin sulfate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Disclaimer

Sales restrictions may apply.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Muta. 1B - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Andrea C Lo et al.
International journal of radiation oncology, biology, physics, 88(5), 1011-1018 (2014-03-26)
We report long-term outcomes and complications of craniopharyngioma patients referred to our institution. Between 1971 and 2010, 123 consecutive patients received primary treatment for craniopharyngioma in British Columbia and were referred to our institution. The median age was 30 years
Sai Ravi Pingali et al.
Cancer, 120(14), 2122-2129 (2014-04-09)
The objective of this study was to compare the outcomes of patients with classical Hodgkin lymphoma (cHL) who achieved complete remission with frontline therapy and then underwent either clinical surveillance or routine surveillance imaging. In total, 241 patients who were
Vincent Murray et al.
Cellular and molecular life sciences : CMLS, 71(8), 1505-1512 (2013-08-29)
The genome-wide pattern of DNA cleavage at transcription start sites (TSSs) for the anti-tumor drug bleomycin was examined in human HeLa cells using next-generation DNA sequencing. It was found that actively transcribed genes were preferentially cleaved compared with non-transcribed genes.
Elika Farrokhi Moshai et al.
American journal of respiratory cell and molecular biology, 51(1), 11-25 (2014-01-24)
Idiopathic pulmonary fibrosis has been associated with the reactivation of developmental pathways, notably the Hedgehog-Glioma-associated oncogene homolog (GLI) pathway. In this study, we determined whether the Hedgehog pathway was activated in bleomycin-induced lung injury in mice, and whether targeting the
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