B3022
二丙酸倍氯米松
analytical standard, for drug analysis
别名:
9-氯-11β,17,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮-17,21-二丙酸酯
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经验公式（希尔记法）:
C28H37ClO7
化学文摘社编号:
分子量:
521.04
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
226-886-0
MDL number:
InChI key
KUVIULQEHSCUHY-XYWKZLDCSA-N
InChI
1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
SMILES string
CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C
assay
≥99%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
veterinary
format
neat
storage temp.
2-8°C
Quality Level
Gene Information
human ... NR3C1(2908)
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General description
Beclomethasone dipropionate belongs to the chemical class of chlorinated glucocorticoid diesters, well known for its use in the treatment of asthma due to its anti-inflammatory properties.
Application
Beclomethasone dipropionate analytical standard can be used as follows:
- Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method, combined with UV detection to determine beclomethasone dipropionate in nanocapsule suspensions
- Simultaneous determination of beclomethasone dipropionate and ketoconazole in their bulk and combined cream formulations using UV-spectrophotometry and RP-HPLC based methods
- Estimation of beclomethasone dipropionate and formoterol fumarate in their combined dosage forms by stability indicating RP-HPLC method coupled with UV detection
- Combined analysis of beclomethasone dipropionate and formoterol fumarate dihydrate using two UV-spectrometric and one RP-HPLC based methods in bulk and their pharmaceutical dosage forms
- Multi-residue analysis of 21 glucocorticoids in environmental samples by ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS)
Other Notes
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Warning
hcodes
Hazard Classifications
Repr. 2 - STOT RE 2
target_organs
Adrenal gland,Immune system,Bone
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Quick Review of Pharmacology null
Jessica K Roberts et al.
The Journal of pharmacology and experimental therapeutics, 345(2), 308-316 (2013-03-21)
Inhaled glucocorticoids, such as beclomethasone dipropionate (BDP), are the mainstay treatment of asthma. However, ≈ 30% of patients exhibit little to no benefit from treatment. It has been postulated that glucocorticoid resistance, or insensitivity, is attributable to individual differences in
Tiago Nunes et al.
Journal of Crohn's & colitis, 7(3), 183-191 (2012-07-13)
IBD is a chronic and relapsing inflammatory disorder of the gut that demands long-lasting treatment targeting both flare-up periods and maintenance of remission. Oral systemic steroids have been used to induce remission in patients with active IBD for over 50
Gail Hayward et al.
The Cochrane database of systematic reviews, 8(8), CD008116-CD008116 (2012-08-17)
The common cold is a frequent illness, which, although benign and self-limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit. Corticosteroids are an effective treatment in other
Kai-Michael Beeh et al.
The Journal of allergy and clinical immunology, 131(3), 866-874 (2013-02-07)
Allergen-specific TH2 responses contribute to the development of allergic asthma. Their increase may be due to a reduced early exposure to environmental pathogens, which induces a TH1 response, and thereby suppresses the allergic TH2 response. QbG10 (bacteriophage Qbeta-derived virus-like particle
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