B5775
苄氟噻嗪
analytical standard
别名:
3-苄基-6-三氟甲基-7-氨磺酰-3,4-二氢-2H-1,2,4-苯并噻二嗪-1,1-二氧化物
等级
analytical standard
质量水平
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
包装形式
neat
SMILES字符串
NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F
InChI
1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
InChI key
HDWIHXWEUNVBIY-UHFFFAOYSA-N
基因信息
human ... SLC12A3(6559)
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一般描述
Bendroflumethiazide belongs to the class of thiazide diuretics, widely used in enhancing diuresis. It is also used as an effective antihypertensive agent and in the treatment of edema caused by cardiac/renal failure and myocardial infarction. Its mode of action involves increasing the urine flow and the net renal excretion of both sodium and water.
应用
Bendroflumethiazide may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A M Healy et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(3), 1182-1186 (2008-07-04)
The purpose of this study was to prepare excipient-free porous microparticles of bendroflumethiazide by spray drying and to characterise the physicochemical properties of the particles produced. Solutions of bendroflumethiazide in ethanol/water, ethanol/water/ammonium carbonate or methanol/water/ammonium carbonate were spray dried using
Quaisar Ali et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 35(6), 654-660 (2012-02-03)
Previously, we demonstrated that angiotensin II type 2 (AT(2)) receptors have a role in natriuresis in obese Zucker rats (OZR). In the present study, we investigated the role of a novel, non-peptide agonist, C21, in natriuresis via AT(2) receptor activation
Hari K Parthasarathy et al.
Journal of hypertension, 28(1), 170-177 (2009-12-17)
We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750
Ibrahim Almuntaser et al.
American journal of hypertension, 22(11), 1227-1231 (2009-09-19)
Diastolic dysfunction is common in early hypertension. We hypothesized that improvement in diastolic dysfunction is blood pressure (BP) dependent and may occur early with treatment in newly diagnosed untreated hypertensive patients. Forty untreated hypertensive subjects (age 52 +/- 1.4 years
Neil R Poulter et al.
Journal of the American College of Cardiology, 54(13), 1154-1161 (2009-09-19)
The aim of this study was to evaluate the effect of baseline heart rate on the efficacy of atenolol-based compared with amlodipine-based therapy in patients with hypertension uncomplicated by coronary heart disease in the ASCOT-BPLA (Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure
Chromatograms
application for HPLC
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