B7522
苯氟雷司 盐酸盐
analytical standard
别名:
N-(1-甲基-2-(3-[三氟甲基]-苯基)乙基]氨基乙醇苯甲酸酯
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关于此项目
经验公式（希尔记法）:
C19H20F3NO2 · HCl
化学文摘社编号:
分子量:
387.82
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
245-801-8
MDL number:
InChI key
NLOALSPYZIIXEO-UHFFFAOYSA-N
InChI
1S/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H
SMILES string
Cl.CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Gene Information
human ... SOAT1(6646)
General description
Benfluorex hydrochloride salt is a hypolipidaemic compound with lipid and glucose lowering effects.
It is used in the treatment of impaired carbohydrate metabolism, atherogenic metabolic disorders and in the suppression of appetite.
It is used in the treatment of impaired carbohydrate metabolism, atherogenic metabolic disorders and in the suppression of appetite.
Application
Benfluorex hydrochloride may be used as a reference standard for characterization of human urinary metabolites of benfluorex by gas chromatography–electron ionization–mass spectrometry (GC-EI-MS) as well as liquid chromatography–electrospray ionization–high resolution/high accuracy tandem mass spectrometry (LC-ESI-MS/MS) method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
此项目有
Agnès Fournier et al.
Pharmacoepidemiology and drug safety, 21(4), 343-351 (2012-02-10)
To estimate the number of deaths from valvular insufficiency caused by the use of the fenfluramine-derivative benfluorex during the period 1976-2009 in France. Our calculation was based on (i) the exposure level to benfluorex in the French population, derived from
Screening for benfluorex and its major urinary metabolites in routine doping controls.
Thevis M, et al.
Analytical and Bioanalytical Chemistry, 401(2), 543-551 (2011)
Thermal and X-ray powder diffraction structural characterization of two benfluorex hydrochloride polymorphs.
Maccaroni E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 53(1), 1-6 (2010)
Can benfluorex induce congenital malformations?
I Lacroix et al.
Diabetes & metabolism, 38(4), 373-374 (2012-05-09)
Geneviève Derumeaux et al.
PloS one, 7(6), e38273-e38273 (2012-06-23)
REGULATE trial was designed to compare the efficacy and safety of benfluorex versus pioglitazone in type 2 diabetes mellitus (DM) patients. Double-blind, parallel-group, international, randomised, non-inferiority trial. More than half of the 196 participating centres were primary care centres. Patients
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