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Merck
CN

BP1103

尼可地尔

British Pharmacopoeia (BP) Reference Standard

别名:

2-(吡啶-3-羰基氨基)乙基硝酸酯, 2-烟酰胺基硝酸乙酯, N-[2-硝氧乙基]-3-吡啶键酰胺, SG-75, 尼可地尔, 烟浪丁

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关于此项目

经验公式（希尔记法）:
C8H9N3O4
化学文摘社编号:
65141-46-0
分子量:
211.17
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00186520

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产品名称

尼可地尔, British Pharmacopoeia (BP) Reference Standard

form

solid

API family

nicorandil

InChI

1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)

SMILES string

[O-][N+](=O)OCCNC(=O)c1cccnc1

InChI key

LBHIOVVIQHSOQN-UHFFFAOYSA-N

grade

pharmaceutical primary standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

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相关类别

Biochem/physiol Actions

尼可地尔是一种杂合ATP敏感性K+（KATP）通道开放剂，也是烟酰胺硝酸盐NO供体。
尼可地尔是一种杂合ATP敏感性K+（KATP）通道开放剂，也是烟酰胺硝酸盐NO供体。尼可地尔能够选择性激活含有SUR2B-和SUR2A-的KATP通道。它可以增强内皮NO合酶的表达，并防止缺血性室性心律失常。尼可地尔通过激活钾离子通道并提供一氧化氮激活鸟苷酸环化酶，引起GMP活化，从而导致动脉和静脉血管舒张。尼可地尔对血管钾离子通道具有选择性，但对心肌收缩和传导没有明显作用。

Application

Nicorandil BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Nicorandil Tablets

    • General description

    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

    Other Notes

    Sales restrictions may apply.

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    pictograms

    FlameExclamation mark
    GHS02,GHS07

    signalword

    Danger

    hcodes

    H242,H302

    Hazard Classifications

    Acute Tox. 4 Oral - Org. Perox. D

    存储类别

    5.2 - Organic peroxides and self-reacting hazardous materials

    wgk

    WGK 1

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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