C0414
克利溴铵
analytical standard
别名:
可立啶
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关于此项目
经验公式（希尔记法）:
C22H26BrNO3
化学文摘社编号:
分子量:
432.35
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
222-471-3
MDL number:
产品名称
克利溴铵, analytical standard
InChI key
WVDSMJSQJXGCNY-UHFFFAOYSA-N
InChI
1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H
SMILES string
Br.C[N]12CCC(CC1)C(C2)OC(=O)C(O)(c3ccccc3)c4ccccc4
grade
analytical standard
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
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Application
Clidinium bromide has been used as an analytical standard for the quantification of the analyte in pharmaceutical formulations using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Clidinium bromide is an anticholinergic, antisecretory and antispasmodic drug, widely used in treating anxiety-related conditions and spastic colon by inhibiting the action of parasympathetic innervations thus decreasing the secretions of stomach acid and slowing the intestines.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
H Valette et al.
European journal of pharmacology, 306(1-3), 133-138 (1996-06-13)
The muscarinic receptor antagonist methyl-quinuclidinyl-benzylate decreased myocardial beta-adrenoceptor density Bmax: 20.4 +/- 2.4 pmol/ml tissue versus 33.3 +/- 4 pmol/ml tissue in control dogs (P < 0.001), as assessed by using [11C]CGP-12177 (((2S)-4-(3-t-butyl-amino-2 hydroxypropoxy)-benzimidazol-2-one)) and positron emission tomography. In contrast
F Brunner et al.
British journal of pharmacology, 102(2), 373-380 (1991-02-01)
1. Muscarinic receptors on endothelial cells of bovine thoracic aorta were characterized by binding assays in which (-)-[3H]-N-methyl quinuclidinyl benzilate ([3H]-NMeQNB) was used as radioligand. 2. Binding of [3H]-NMeQNB to crude membranes of freshly isolated endothelial cells was atropine-displaceable and
Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry
Toral I.M, et al.
The Veterinary Quarterly, 189(1), 67-74 (1999)
D Le Guludec et al.
Circulation, 90(1), 172-178 (1994-07-01)
Decreased myocardial adenylate cyclase activity in response to guanine nucleotide stimulation has been recently demonstrated in denervated myocardium of transplant patients, suggesting that changes in left ventricular muscarinic receptors may occur. The concentration and affinity constants of myocardial muscarinic receptors
H Yazawa et al.
The Journal of urology, 152(6 Pt 1), 2173-2177 (1994-12-01)
We obtained a primary culture of prostatic cells by an explant method from patients with benign prostatic hypertrophy (BPH). Ultrastructural morphology and growth characteristics of these cells conformed to those reported for smooth muscle cells isolated from vascular and visceral
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