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Merck
CN

C1653

可待因 溶液

analytical standard, for drug analysis, 1.0 mg/mL in methanol

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经验公式（希尔记法）:
C18H21NO3
化学文摘社编号:
76-57-3
分子量:
299.36
UNSPSC Code:
41116107
PubChem Substance ID:
329774901
EC Number:
200-659-6
MDL number:
MFCD00190150

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InChI key

OROGSEYTTFOCAN-DNJOTXNNSA-N

InChI

1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

SMILES string

[H][C@@]12Oc3c(OC)ccc4C[C@H]5N(C)CC[C@@]1(c34)[C@@]5([H])C=C[C@@H]2O

agency

EPA 1694

drug control

Home Office Schedule 2; stupéfiant (France)

concentration

1.0 mg/mL in methanol

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

environmental
pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

Gene Information

human ... CYP2D6(1565), OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

flash_point_c

11 °C - closed cup

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup

ppe

Eyeshields, Faceshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
060M8703V
060M8703
SLBD4143V
101M8707V
101M8707

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Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF-induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis correct? Wheal and flare responses
Laurence Toms et al.
The Cochrane database of systematic reviews, (1)(1), CD001547-CD001547 (2009-01-23)
This is an updated version of the Cochrane review published in Issue 4, 1998. Combining drugs from different classes with different modes of action may offer opportunity to optimise efficacy and tolerability, using lower doses of each drug to achieve
Codeine phosphate in paediatric medicine.
D G Williams et al.
British journal of anaesthesia, 86(3), 413-421 (2001-09-28)
Is it farewell to codeine?
Brian J Anderson
Archives of disease in childhood, 98(12), 986-988 (2013-08-27)
Lauren E Kelly et al.
Therapeutic drug monitoring, 34(3), 249-256 (2012-05-10)
Codeine is an old and commonly used analgesic agent for mild to moderate pain. It is the prototypical "prodrug" in that its analgesic effect is almost wholly dependent on its biotransformation to morphine, a process that is mediated by the
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