InChI
1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+
SMILES string
CCN(C(=O)\C=C\C)c1ccccc1C
InChI key
DNTGGZPQPQTDQF-XBXARRHUSA-N
grade
pharmaceutical primary standard
description
predominantly trans
API family
crotamiton
manufacturer/tradename
EDQM
refractive index
n20/D 1.54 (lit.)
bp
153-155 °C/13 mmHg (lit.)
density
0.987 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Crotamiton EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
Noriko Ohtaki et al.
The Journal of dermatology, 30(5), 411-416 (2003-05-30)
We report two cases of scabies treated with oral ivermectin (200 micro g/kg). Case 1, a 72-year-old man, developed crusted scabies with the use of oral corticosteroids due to a misdiagnosis by an earlier physician. The patient was successfully treated
E Dika et al.
Cutaneous and ocular toxicology, 25(3), 211-216 (2006-09-19)
Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin. We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose
Rika Sekine et al.
Experimental dermatology, 21(3), 201-204 (2012-03-03)
Itch accompanies various skin diseases. As a number of mediators other than histamine can be involved in the itch sensation, H1 receptor antagonists are not necessarily effective in treating itch. External application of antipruritic drugs is occasionally used as an
Maria Wesołowska et al.
Wiadomosci parazytologiczne, 51(3), 253-256 (2006-08-18)
Demodex mites are common parasites in the hair follicles and in the pilosebaceous glands. Demodex folliculorum and D. brevis have been identified in humans and play a role in three facial conditions: Pityriasis folliculorum, rosacea-like demodicidosis and Demodicidosis gravis. The
F Forton et al.
The British journal of dermatology, 138(3), 461-466 (1998-05-15)
A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5D/cm2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical
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