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Merck
CN

C3607

氰钴胺

meets USP testing specifications

别名:

维生素 B 12, α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, 氰钴胺

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关于此项目

经验公式（希尔记法）:
C63H88CoN14O14P
化学文摘社编号:
68-19-9
分子量:
1355.37
MDL number:
MFCD00151092
UNSPSC Code:
12352205
eCl@ss:
34058004
PubChem Substance ID:
24892627
EC Number:
200-680-0
NACRES:
NA.21
Beilstein/REAXYS Number:
4122889

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产品名称

氰钴胺, meets USP testing specifications

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

agency

USP/NF
meets USP testing specifications

assay

96.0-102.0% dry basis

form

powder

color

dark red

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

氰钴维生素已被用于研究其对预防结肠癌的作用。
细胞体外生长、基因稳定性和生存所必需成分。可支持单碳代谢。存在于许多经典和无血清配方中。

Biochem/physiol Actions

氰钴维生素可用于制备多种维生素补充剂和强化食品。其可用作辅酶，在异构酶催化下将L-甲基丙二酰辅酶A转化为琥珀酰辅酶A。氰钴维生素可于治疗维生素B12缺乏症。氰钴维生素符合USP测试规范。

General description

氰钴维生素(B12)是一种水溶性维生素，主要存在于乳制品、肉类和蛋类等动物产品中。它属于B12类维生素，通常称为钴胺素。氰钴维生素由四个吡咯环和一个中心钴原子由四个赤道含氮配体配位而成。

存储类别

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000455525
0000455525
0000497663
0000497663
0000448733

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Dose-Dependent Effect of Cyanocobalamin on the Prevention of Colon Cancer: An In Vivo Study
Padmanabhan S, et al.
EC nutrition, 13, 563-571 (2018)
Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial
Eussen SJPM, et al.
Archives of Internal Medicine, 165(10), 1167-1172 (2005)
Determination of cyanocobalamin by isotope dilution LC-MS/MS
D Ulivo L, et al.
Analytica Chimica Acta, 990, 103-109 (2017)
Tóshiko Takahashi-Iñiguez et al.
Journal of Zhejiang University. Science. B, 13(6), 423-437 (2012-06-05)
Vitamin B(12) is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes, which have been grouped into three subfamilies depending on their cofactors. Among them, methylmalonyl-CoA mutase (MCM) has been extensively studied. This enzyme catalyzes
David Preiss et al.
The lancet. Diabetes & endocrinology, 2(2), 116-124 (2014-03-14)
Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes. We did a single-centre, double-blind, placebo-controlled trial at the Glasgow
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