C4206
卡马西平 10,11-环氧化物
analytical standard
别名:
1a,10b-二氢-6H-二苯并(b,f)环氧乙烯并[d]氮呯-6-甲酰胺
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关于此项目
经验公式（希尔记法）:
C15H12N2O2
化学文摘社编号:
分子量:
252.27
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
卡马西平 10,11-环氧化物, analytical standard
InChI
1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)
SMILES string
NC(=O)N1c2ccccc2C3OC3c4ccccc14
InChI key
ZRWWEEVEIOGMMT-UHFFFAOYSA-N
grade
analytical standard
assay
≥98% (HPLC)
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
−20°C
Quality Level
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Application
卡马西平10,11-环氧化物可用作测试材料，用于荧光HDAC活性测定法以定量组蛋白脱乙酰酶（HDAC）抑制。
有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
Biochem/physiol Actions
卡马西平的第一代谢产物
General description
卡马西平10,11-环氧化物是药物卡马西平的代谢产物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
G Bellucci et al.
Journal of medicinal chemistry, 30(5), 768-773 (1987-05-01)
Carbamazepine 10,11-oxide (1a,10b-dihydro-6H-dibenzo[b,f]oxireno[d]azepine-6-carboxamide), a key intermediate in carbamazepine metabolism, was found to be unusually resistant to enzymatic hydrolysis when incubated with microsomal and cytosolic fractions from rabbit, rat, and guinea pig livers. However, its hydrolysis product, trans-10,11-dihydro-10,11-dihydroxy-5H-dibenzo[b,f]azepine-5-carboxamide , was excreted
L Bertilsson et al.
Clinical pharmacokinetics, 11(3), 177-198 (1986-05-01)
Carbamazepine is a first-line drug in the treatment of most forms of epilepsy and also the drug of first choice in trigeminal neuralgia. Furthermore, it is now frequently used in bipolar depression. Most oral formulations of carbamazepine are well absorbed
Ping Ji et al.
Journal of clinical pharmacology, 48(8), 948-956 (2008-06-04)
The effect of efavirenz on the pharmacokinetics of carbamazepine and vice versa was investigated in adult healthy subjects in a randomized, open-label, 2-period crossover, multiple-dose study. Subjects were randomized to receive either efavirenz 600 mg qd for 14 days or
Luciana Vera-Candioti et al.
Electrophoresis, 29(22), 4527-4537 (2008-11-28)
Drug monitoring in serum samples was performed using second-order data generated by CE-DAD, processed with a suitable chemometric strategy. Carbamazepine could be accurately quantitated in the presence of its main metabolite (carbamazepine epoxide), other therapeutic drugs (lamotrigine, phenobarbital, phenytoin, phenylephrine
Ying-Chang Chi et al.
Toxicology and applied pharmacology, 263(3), 315-322 (2012-07-21)
Carbamazepine (CBZ), an antiepileptic with narrow therapeutic window, is a substrate of CYP 3A which metabolizes CBZ to carbamazepine-10,11-epoxide (CBZE), an active metabolite. This study investigated the acute and chronic effects of Polygonum cuspidatum (PC), a resveratrol-rich nutraceutical, on the
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