C6272
克罗米酚 柠檬酸盐
analytical standard
别名:
枸橼酸氯米芬
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关于此项目
经验公式（希尔记法）:
C26H28ClNO · C6H8O7
化学文摘社编号:
分子量:
598.08
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-035-3
MDL number:
InChI key
PYTMYKVIJXPNBD-BTKVJIOYSA-N
InChI
1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25+;
SMILES string
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCOc1ccc(cc1)\C(=C(\Cl)c2ccccc2)c3ccccc3
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
General description
Clomiphene is an semisynthetic antiestrogen, widely used in the treatment of infertility by inducing ovulation and stimulating sperm production. It is also used in the treatment of breast cancer.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
顺反异构体混合物
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
A method by homemade OH/TSO-PMHS fibre solid-phase microextraction coupling with gas chromatography?mass spectrometry for analysis of antiestrogens in biological matrices
Liu W, et al.
Analytica Chimica Acta, 631(1), 47-53 (2009)
Ritsa Storeng et al.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 132(22), 2494-2499 (2013-01-23)
A possible correlation between hormonal stimulation during treatment of infertility and the risk of cancer of the breast, the ovaries, the cervix or the uterus has been investigated in a number of epidemiological studies. The purpose of this article is
G Eleftheriou et al.
Clinical and experimental obstetrics & gynecology, 39(4), 535-536 (2013-03-01)
Clomiphene is widely used for inducing ovulation. Evidence for congenital abnormalities, in particular central nervous system defects (CNS-D) and in babies born from clomiphene-induced pregnancies is conflicting. The authors report a case of holoprosencephalia (HPE) in a fetus delivered from
M J Nahuis et al.
Human reproduction (Oxford, England), 27(12), 3577-3582 (2012-09-25)
Laparoscopic electrocautery of the ovaries and ovulation induction with gonadotrophins are both second line treatments for women with clomiphene citrate-resistant polycystic ovary syndrome (PCOS). Long-term follow-up after electrocautery versus ovulation induction with gonadotrophins has demonstrated at least comparable chances for
Rebecca S Usadi et al.
Current opinion in endocrinology, diabetes, and obesity, 19(6), 505-511 (2012-10-31)
The purpose of this review is to highlight the impact of polycystic ovary syndrome (PCOS) on menstrual function, fertility and reproductive outcomes. Women with PCOS often present with anovulation, menstrual disturbances and hyperandrogenism. Management options for the reproductive disorders of
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