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Merck
CN

C8037

丙酸氯倍他索

analytical standard

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关于此项目

经验公式（希尔记法）:
C25H32ClFO5
化学文摘社编号:
25122-46-7
分子量:
466.97
NACRES:
NA.24
PubChem Substance ID:
329775158
UNSPSC Code:
41116107
EC Number:
246-634-3
MDL number:
MFCD00058499

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产品名称

丙酸氯倍他索, analytical standard

InChI key

CBGUOGMQLZIXBE-XGQKBEPLSA-N

InChI

1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

SMILES string

CCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CCl

grade

analytical standard

assay

≥98%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... NR3C1(2908)
rat ... Nr3c1(24413)

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相关类别

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Clobetasol propionate is a novel and highly potent, topical corticosteroid, which is being assessed for its utility in the treatment of bullous pemphigoid.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B - STOT RE 2

target_organs

Adrenal gland,Immune system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF5836V
WXBF3427V
WXBF2638V
WXBF0008V
WXBD9233V

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Treatment of bullous pemphigoid with topical clobetasol propionate
Westerhof W
Journal of the American Academy of Dermatology, 20, 458-461 (1989)
Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases
Lozada-Nur F, et al.
Oral Surgery, Oral Medicine, and Oral Pathology, 71, 283-287 (1991)
Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases.
Lozada-Nur F and Huang M Z
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 71(3), 283-287 (1991)
Treatment of bullous pemphigoid with topical clobetasol propionate.
Westerhof W.
Journal of the American Academy of Dermatology, 20(3), 458-461 (1989)
S R Wiegell et al.
The British journal of dermatology, 171(6), 1487-1492 (2014-07-26)
Photodynamic therapy (PDT) is an effective and established treatment for actinic keratoses (AK) and nonmelanoma skin cancer. The main side-effects of PDT are post-treatment erythema and oedema, and pain during illumination. Severe erythema after PDT enhances the down time associated
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