C8856
卡托普利
meets USP testing specifications
别名:
N-[(S)-3-巯基-2-甲基丙酰基]-L-脯氨酸
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关于此项目
经验公式（希尔记法）:
C9H15NO3S
化学文摘社编号:
分子量:
217.29
UNSPSC Code:
41116107
NACRES:
NA.21
PubChem Substance ID:
EC Number:
263-607-1
Beilstein/REAXYS Number:
477887
MDL number:
InChI key
FAKRSMQSSFJEIM-RQJHMYQMSA-N
InChI
1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
SMILES string
C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
biological source
synthetic (organic)
agency
USP/NF, meets USP testing specifications
assay
97.5-102.0% dry basis
form
crystalline
mp
104-108 °C (lit.)
storage temp.
room temp
Quality Level
Gene Information
human ... ACE(1636), ECE1(1889)
rat ... Ace(24310)
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Biochem/physiol Actions
血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成，血管紧张素 II 是生物活性多肽，可促进血管生成并增加微血管密度。
signalword
Danger
hcodes
Hazard Classifications
Muta. 2 - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Peter Vella et al.
Bioorganic & medicinal chemistry letters, 21(11), 3282-3285 (2011-05-04)
The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections. This work describes the discovery of lead compounds for the development of new inhibitors using a
Donna H Lee et al.
American journal of physiology. Cell physiology, 304(2), C147-C163 (2012-11-02)
The renal distal tubule Na-Cl cotransporter (NCC) reabsorbs <10% of the filtered Na(+) but is a key control point for blood pressure regulation by angiotensin II (ANG II), angiotensin-converting enzyme inhibitors (ACEI), and thiazide diuretics. This study aimed to determine
Faridoon et al.
Bioorganic & medicinal chemistry letters, 22(1), 380-386 (2011-11-26)
The production of β-lactamases is an effective strategy by which pathogenic bacteria can develop resistance against β-lactam antibiotics. While inhibitors of serine-β-lactamases are widely used in combination therapy with β-lactam antibiotics, there are no clinically available inhibitors of metallo-β-lactamases (MBLs)
Antonio C M Camargo et al.
Toxicon : official journal of the International Society on Toxinology, 59(4), 516-523 (2011-08-13)
The identification of novel endogenous and exogenous molecules acting in the complex mechanism of regulating the vascular tonus has always been of great interest. The discovery of bradykinin (1949) and the bradykinin-potentiating peptides (1965) had a pivotal influence in the
Samir Attoub et al.
Annals of the New York Academy of Sciences, 1138, 65-72 (2008-10-08)
Lung cancer is the most common form of cancer in the world, and 90% of patients die from their disease. The angiotensin converting enzyme (ACE) inhibitors are used widely as antihypertensive agents, and it has been suggested that they decrease
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