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Merck
CN

C8981

卡马西平

meets USP testing specifications

别名:

5H-二苯并[b,f]氮杂-5-甲酰胺

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关于此项目

经验公式（希尔记法）:
C15H12N2O
化学文摘社编号:
298-46-4
分子量:
236.27
NACRES:
NA.21
PubChem Substance ID:
24893120
UNSPSC Code:
41116107
EC Number:
206-062-7
MDL number:
MFCD00005073

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产品名称

卡马西平, meets USP testing specifications

InChI key

FFGPTBGBLSHEPO-UHFFFAOYSA-N

InChI

1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

SMILES string

NC(=O)N1c2ccccc2C=Cc3ccccc13

agency

USP/NF
meets USP testing specifications

form

solid

mp

191-192 °C (lit.)

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... PRNP(5621), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)

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Biochem/physiol Actions

抗惊厥药；GABAA受体苯二氮卓调节位点的配体。钠离子通道抑制剂。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3

target_organs

Central nervous system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCT6391
MKCK0972
MKCR2920
MKCD8191
MKBZ7693V

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U Amstutz et al.
Clinical pharmacology and therapeutics, 94(1), 142-149 (2013-04-17)
The occurrence of hypersensitivity reactions including rare but life-threatening Stevens-Johnson syndrome (SJS) and drug-induced hypersensitivity syndrome (HSS) limits the use of the anticonvulsant carbamazepine (CBZ). Human leukocyte antigen-B (HLA)-B 15:02 and HLA-A 31:01 have been identified as predictive genetic markers
Ursula Amstutz et al.
Epilepsia, 55(4), 496-506 (2014-03-07)
To systematically review evidence on genetic risk factors for carbamazepine (CBZ)-induced hypersensitivity reactions (HSRs) and provide practice recommendations addressing the key questions: (1) Should genetic testing for HLA-B*15:02 and HLA-A*31:01 be performed in patients with an indication for CBZ therapy
Janneke Jentink et al.
BMJ (Clinical research ed.), 341, c6581-c6581 (2010-12-04)
To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy. A review of all published cohort studies to identify key indications and a population based case-control study to test these indications. Review of
Evan A Thomas et al.
Epilepsia, 54(7), 1195-1202 (2013-04-10)
A common notion of the mechanism by which the antiepileptic drugs (AEDs) carbamazepine and phenytoin act is that they block sodium channels by binding preferentially to the inactivated state, thereby allowing normal neuronal firing while blocking ictal activity. However, these
Felix M Rivas et al.
Journal of medicinal chemistry, 52(7), 1795-1798 (2009-03-12)
The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described. These BDZs have selective efficacy for alpha2beta3gamma2 and alpha3beta3gamma2 GABA(A)-receptors. Significant anticonvulsant activity with little or no motor impairment and therapeutic indexes (TI) of
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