Merck
CN
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文件

E1271

Sigma-Aldrich

N -乙基马来酰亚胺

BioXtra, ≥98% (HPLC)

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别名:
NEM
经验公式（希尔记法）:
C6H7NO2
CAS号:
128-53-0
分子量:
125.13
Beilstein:
112448
EC 号:
204-892-4
MDL编号:
MFCD00005509
PubChem化学物质编号:
24894398
NACRES:
NA.21

产品线

BioXtra

质量水平

200

检测方案

≥98% (HPLC)

杂质

≤0.001% Phosphorus (P)
≤0.1% Insoluble matter

灼烧残渣

≤0.1%

bp

210 °C (lit.)

mp

43-46 °C (lit.)

溶解性

95% ethanol: 50 mg/mL, clear to slightly hazy (colorless to faint yellow)

痕量阴离子

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

痕量阳离子

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

储存温度

2-8°C

SMILES string

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChI key

HDFGOPSGAURCEO-UHFFFAOYSA-N

Gene Information

human ... SLC6A3(6531) , SLC6A4(6532)

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相关类别

应用

用于共价修饰蛋白质的半胱氨酸残基的试剂。

生化/生理作用

使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化剂。
增强来自交感神经元的原生 M 通道的电流，并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。

象形图

CorrosionSkull and crossbones
GHS05,GHS06

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

163.2 °F

闪点(°C)

72.9 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Tatsuki Kurokawa et al.
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Dar'ya S Redka et al.
Biochemistry, 52(42), 7405-7427 (2013-09-21)
Muscarinic and other G protein-coupled receptors exhibit an agonist-specific heterogeneity that tracks efficacy and commonly is attributed to an effect of the G protein on an otherwise homogeneous population of sites. To examine this notion, M2 muscarinic receptors were purified
Nicolas Matuszak et al.
Journal of medicinal chemistry, 52(23), 7410-7420 (2009-07-09)
The endocannabinoid 2-arachidonoylglycerol (2-AG) plays a major role in many physiological processes, and its action is quickly terminated via enzymatic hydrolysis catalyzed by monoglyceride lipase (MGL). Regulating its endogenous level could offer therapeutic opportunities; however, few selective MGL inhibitors have
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Proceedings of the National Academy of Sciences of the United States of America, 110(41), E3955-E3964 (2013-09-26)
Atrial myocytes are continuously exposed to mechanical forces including shear stress. However, in atrial myocytes, the effects of shear stress are poorly understood, particularly with respect to its effect on ion channel function. Here, we report that shear stress activated
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Conditions causing an increase in misfolded or aberrant proteins can impair the activity of the ubiquitin/proteasome system (UPS). This observation is of particular interest, given the fact that proteotoxic stress is closely associated with a large variety of disorders. Although
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