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经验公式（希尔记法）:
C14H16N2O2
化学文摘社编号:
分子量:
244.29
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI key
NPUKDXXFDDZOKR-LLVKDONJSA-N
SMILES string
CCOC(=O)c1cncn1[C@H](C)c2ccccc2
InChI
1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
grade
pharmaceutical primary standard
API family
etomidate
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Etomidate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
依托咪酯(Etomidate)是一种全身麻醉药；可激活GABAA 信号通路
依托咪酯(Etomidate)是一种全身麻醉药；可激活GABAA信号通路。已有研究，依托咪酯对大鼠脑和脊髓中链脲菌素诱导(STZ-induced)的高血糖具有神经保护作用。依托咪酯治疗对神经组织具有抗糖尿病氧化损伤的神经保护作用。
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
microRNA expression and its potential role in cardioprotection by ischemic postconditioning in pigs.
Theodor Baars et al.
Pflugers Archiv : European journal of physiology, 466(10), 1953-1961 (2014-01-07)
Ischemic postconditioning (PoCo) reduces infarct size following myocardial ischemia/reperfusion. To protect, PoCo must be performed early during reperfusion, and causal cardioprotective signaling must occur then. The role of microRNA (miRNA) in PoCo is unclear. Anesthetized pigs were subjected to 60
Stuart A Forman
Anesthesiology, 114(3), 695-707 (2011-01-26)
This review focuses on the unique clinical and molecular pharmacologic features of etomidate. Among general anesthesia induction drugs, etomidate is the only imidazole, and it has the most favorable therapeutic index for single-bolus administration. It also produces a unique toxicity
Stewart G Albert et al.
Intensive care medicine, 37(6), 901-910 (2011-03-05)
Although etomidate is a preferred anesthetic agent for rapid sequence intubation (RSI) in critical illness, as an inhibitor of cortisol synthesis (11β-hydroxylase), it may be associated with adrenal dysfunction. The objectives are to review the effects of etomidate versus comparator
Veronica A Preda et al.
European journal of endocrinology, 167(2), 137-143 (2012-05-12)
This review addresses the practical usage of intravenous etomidate as a medical therapy in Cushing's syndrome. We reviewed the relevant literature, using search terms 'etomidate', 'Cushing's syndrome', 'adrenocortical hyperfunction', 'drug therapy' and 'hypercortisolaemia' in a series of public databases. There
Antoine J Cherfan et al.
Pharmacotherapy, 32(5), 475-482 (2012-04-11)
Etomidate is a potent imidazole hypnotic used widely in single doses in the rapid sequence intubation of critically ill patients with sepsis due to its presumed hemodynamic safety, fast onset, and short duration of action. However, the literature is conflicting
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