F6145
芬司匹利 盐酸盐
analytical standard, for drug analysis
别名:
8-(2-苯乙基)-1-氧杂-3,8-二氮杂螺[4.5]癸烷-2-酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C15H20N2O2 · HCl
化学文摘社编号:
分子量:
296.79
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
225-752-9
MDL number:
grade
analytical standard
Quality Level
assay
>99% (TLC)
form
powder
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1
InChI
1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
InChI key
FIKFLLIUPUVONI-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), HRH1(3269)
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.
Fenspiride hydrochloride possesses anti-allergic and anti-bronchoconstrictive properties. It is used as a drug to treat inflammatory conditions of the upper and lower respiratory tracts. Experimental studies state that fenspiride has an ability to reduce the development of myringosclerosis, possibly by restricting the formation of oxygen-derived free radicals.
Fenspiride hydrochloride possesses anti-allergic and anti-bronchoconstrictive properties. It is used as a drug to treat inflammatory conditions of the upper and lower respiratory tracts. Experimental studies state that fenspiride has an ability to reduce the development of myringosclerosis, possibly by restricting the formation of oxygen-derived free radicals.
具有抗炎功能的支气管扩张药。通过其抗毒蕈碱作用，在接头前水平抑制黏液分泌并降低速激肽的释放。它还可以是 α 肾上腺素和 H1 组胺受体的拮抗剂
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
F Quartulli et al.
European journal of pharmacology, 348(2-3), 297-304 (1998-07-04)
Using the human lung epithelial WI26VA4 cell line, we investigated the capacity of fenspiride, an anti-inflammatory drug with anti-bronchoconstrictor properties, to interfere with histamine-induced intracellular Ca2+ increase and eicosanoid formation. Histamine and a histamine H1 receptor agonist elicited a rapid
J C Féray et al.
Biochemical pharmacology, 54(2), 293-297 (1997-07-15)
Fenspiride inhibits the calcium signal evoked by the inflammatory peptide formyl-Met-Leu-Phe (fMLP) in peritoneal macrophages, but at concentrations (approximately 1 mM) far above the therapeutic range (approximately 1 microM). Here, in rat alveolar macrophages, high fenspiride concentrations (1 mM) were
Inhibition of the development of myringosclerosis by local administration of fenspiride, an anti-inflammatory drug.
Mattsson C and Hellstrom S
European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 254(9-10), 425-429 (1997)
J Cortijo et al.
European journal of pharmacology, 341(1), 79-86 (1998-03-07)
We have investigated the role of human bronchial cyclic nucleotide phosphodiesterases in the effects of fenspiride, a drug endowed with bronchodilator and anti-inflammatory properties. Functional studies on human isolated bronchi showed that fenspiride (10(-6)-3 x 10(-3) M, 30 min) induced
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