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经验公式（希尔记法）:
C21H27N5O4S
化学文摘社编号:
分子量:
445.54
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
SMILES string
Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
InChI key
ZJJXGWJIGJFDTL-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
glipizide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... ABCC8(6833), KCNJ11(3767)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Glipizide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
H E Lebovitz
Pharmacotherapy, 5(2), 63-77 (1985-03-01)
Glipizide is a second-generation sulfonylurea in which the substitutions on the arylsulfonylurea nucleus are large, relatively nonpolar groups. This chemical change increases the intrinsic hypoglycemic activity of the molecule 100-fold on a weight basis compared to first-generation agents. In addition
[Glipizide a new oral antidiabetic agent (comprehensive review)].
E Brunová
Vnitrni lekarstvi, 22(6), 595-599 (1976-06-01)
M Małecki
Przeglad lekarski, 53(9), 663-665 (1996-01-01)
The structure and effect of glipizide, the second generation derivates of sulfonylurea were described. The special role in the treatment of polymetabolic syndrome of this drug was stressed.
Glipizide: an oral hypoglycemic drug.
G Wensing
The American journal of the medical sciences, 298(1), 69-71 (1989-07-01)
Zahra N Mahmoudi et al.
The AAPS journal, 16(4), 685-697 (2014-05-03)
Preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, often a single polymer may not bring about a significant enhancement in solubility or amorphous stability of a
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