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Merck
CN

G1914

庆大霉素 硫酸酯

meets USP testing specifications, powder

别名:

庆大霉素 硫酸盐, 庆大霉素 C, 正泰霉素

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关于此项目

化学文摘社编号:
MDL number:
UNSPSC Code:
51281651
eCl@ss:
42020823
PubChem Substance ID:
EC Number:
215-778-9
NACRES:
NA.76
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产品名称

庆大霉素 硫酸酯, meets USP testing specifications, powder

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI key

RDEIXVOBVLKYNT-HDZPSJEVSA-N

SMILES string

O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[

biological source

Micromonospora purpurea

agency

USP/NF
meets USP testing specifications

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

application(s)

pharmaceutical (small molecule)

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

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Application

硫酸庆大霉素,是一种广谱抗生素,在细胞培养和分子生物实验中作为选择剂(抗庆大霉素基因)。 产品推荐使用浓度是50mg/L。

Biochem/physiol Actions

作用机制:庆大大霉素通过和30S核糖亚基结合,引起密码子误读,阻碍肽酰转移酶从供体位点转移到受体位点。庆大霉素通过它与外膜的结合来发挥它对铜绿假单胞菌的杀菌作用,它在外膜上置换天然阳离子,使膜不稳定,并在细胞表面形成孔。

抗菌谱:包括革兰氏阴性和革兰氏阳性细菌,包括对于四环素、氯霉素、卡那霉素和粘菌素,某些特定假单胞菌菌株,变形杆菌属,StaphylococcusStreptococcus 的抗性。

Disclaimer

无菌溶液需要储存在2-8℃。溶液在室温下和烧开的水性缓冲液,pH2-142下稳定。

General description

化学结构:氨基糖苷类

Other Notes

庆大霉素是Micromonospora purpurea M. echinospora发酵后产生的氨基糖苷复合物。 它可以用来作为硫酸盐。 每摩尔庆大霉素基础有三个成分,每一个成分包含五份碱性氮,并且需要5份硫酸。

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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