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Merck
CN

G2289

Glycerol

greener alternative

meets USP testing specifications

别名:

甘油, 1,2,3-丙三醇

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线性分子式:
HOCH2CH(OH)CH2OH
化学文摘社编号:
56-81-5
分子量:
92.09
NACRES:
NA.21
PubChem Substance ID:
24895092
UNSPSC Code:
12352201
EC Number:
200-289-5
MDL number:
MFCD00004722
Beilstein/REAXYS Number:
635685

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产品名称

甘油, meets USP testing specifications

InChI key

PEDCQBHIVMGVHV-UHFFFAOYSA-N

InChI

1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

SMILES string

OCC(O)CO

biological source

plant (palm)

agency

USP/NF
meets USP testing specifications

vapor density

3.1 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

assay

99.0-101.0% anhydrous basis

form

viscous liquid

autoignition temp.

698 °F

greener alternative product characteristics

Safer Solvents and Auxiliaries
Design for Degradation
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

cryopreservation: suitable
immunofluorescence: suitable

impurities

<0.01% Ash
<5% water (Karl Fischer)

refractive index

n20/D 1.474 (lit.)

bp

182 °C/20 mmHg (lit.)

mp

20 °C (lit.)

solubility

water: miscible

density

1.25 g/mL (lit.)

application(s)

agriculture
life science and biopharma
pharmaceutical (small molecule)
sample preparation

greener alternative category

Aligned

Quality Level

300

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相关类别

Application

甘油已用于：

  • 作为样品培养基中的冷冻保护剂，用于植物生理学相关的研究
  • 作为光学透明剂，用于谐波产生显微镜研究

Features and Benefits

  • 可用于代谢组学和生物化学研究
  • 用于多种研究应用的优质化合物

General description

甘油，也称为丙三醇或 1,2,3-丙三醇，是一种用途非常广泛的化合物，具有三个羟基，使其在水中具有很强的溶解度，并使其具有吸湿性。这种简单但广泛使用的物质具有多方面的应用，既可以作为碳源，也可以作为多种化学和生物过程的前体。在生物技术领域，甘油是各种微生物不可或缺的资源，当用作唯一的碳和能源时，甘油使得它们能够生产各种各样的生物产物。此外，甘油在样品制备中具有广泛的用途，它可以提高样品密度并防止样品冻结。甘油′的重要性超越了生物技术，因为它在样品制备（例如电泳凝胶创建）方面表现出色。使用浓度为 5% 至 10% 的甘油来提高样品密度，确保凝胶底部的精确分层。这种多功能化合物还有助于浇铸梯度凝胶，并作为蛋白质的稳定剂，同时在存储缓冲液中发挥关键作用。它也是酶浓缩和储存的首选，可有效防止蛋白质反向扩散到缓冲液中。在细胞培养方面，甘油证明了其作为冷冻保护剂的价值，可降低培养基的冰点，并保护细胞在 -80°C 冷冻和储存过程中免受冰晶损伤。甘油在生化研究领域的样品保存和储存中起着至关重要的作用。单独冷冻细菌培养物可能会产生有害影响，由于冰晶形成而导致脱水和蛋白质变性。通过加入甘油，可以缓解这些问题，确保了细菌培养物的有效保存。将细菌培养物储存在甘油原液中可确保稳定性，防止细胞膜受损并保持细胞活力，从而实现长期储存。在实验室研究中，保持样品完整性是很重要的，甘油′在此过程中发挥着重要作用，尤其是在 -80°C 的超低温冰箱中储存时，可保持样品完整性并确保其适合广泛的分析和研究。
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. Glycerol, with its high boiling point, low flammability, and polarity, is a standout choice. As a non-toxic and biodegradable compound, it aligns perfectly with the principles of ′Safer Solvents and Auxiliaries′ and ′Design for Degradation′. Click here for more information.

Other Notes

如需了解生化试剂系列的更多信息，请填写此表。

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

390.2 °F - Pensky-Martens closed cup

flash_point_c

199 °C - Pensky-Martens closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SHBT5059
SHBT1855
SHBT0757
SHBS6251
SHBS3983

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Jia-Hong Lai et al.
Scientific reports, 11(1), 329-329 (2021-01-13)
Imaging depth and quality of optical microscopy can be enhanced by optical clearing. Here we investigate the optical clearing of the ex vivo human skin by 50% glycerol topical application, which is allowed for cosmetic usage. Harmonic generation microscopy, by
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