所有图片(1)

文件

G2539

格列本脲

Name: 格列本脲
Brand: SIAL

meets USP testing specifications

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别名:

格列本脲, 5-氯-N-[4-(环己基脲磺酰)苯乙基]-2-甲氧基苯甲酰胺, N-对[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰基-N′-环己基脲

经验公式（希尔记法）:

C₂₃H₂₈ClN₃O₅S

CAS号:

10238-21-8

分子量:

494.00

EC 号:

233-570-6

MDL编号:

MFCD00056625

PubChem化学物质编号:

24895097

NACRES:

NA.21

Agency

USP/NF
meets USP testing specifications

质量水平

200

application(s)

pharmaceutical (small molecule)

储存温度

2-8°C

SMILES string

COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3

InChI

1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

InChI key

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

Gene Information

human ... ABCC8(6833) , KCNH2(3757) , KCNJ11(3767)
rat ... Kcnj1(24521)

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危险声明

H413

预防措施声明

P273 - P501

危险分类

Aquatic Chronic 4

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Glibenclamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Ruchira M Jha et al.

Journal of neurotrauma, 38(5), 628-645 (2020-11-19)

Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (TBI). Adult Sprague-Dawley rats underwent fluid percussion injury (FPI; n = 45), controlled cortical impact (CCI;

The effect of Glibenclamide on somatosensory evoked potentials after cardiac arrest in rats.

Lachance, et al.

Neurocritical Care, 36, 612-620 (2023)

A binary QSAR model for classification of hERG potassium channel blockers.

Khac-Minh Thai et al.

Bioorganic & medicinal chemistry, 16(7), 4107-4119 (2008-02-05)

Acquired long QT syndrome causes severe cardiac side effects and represents a major problem in clinical studies of drug candidates. One of the reasons for development of arrhythmias related to long QT is inhibition of the human ether-a-go-go-related-gene (hERG) potassium

Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS-Based Detection Methods.

Lisa D Marroquin et al.

Current protocols in toxicology, 71, 14-14 (2017-02-02)

The bile salt export pump (BSEP, ABCB11) belongs to the ATP-binding-cassette superfamily of transporters and is predominately found in the liver. BSEP is an efflux transporter that plays a critical role in the secretion of bile salts into the bile.

Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke.

Jesse A Stokum et al.

Science signaling, 16(788), eadd6364-eadd6364 (2023-06-06)

Brain swelling causes morbidity and mortality in various brain injuries and diseases but lacks effective treatments. Brain swelling is linked to the influx of water into perivascular astrocytes through channels called aquaporins. Water accumulation in astrocytes increases their volume, which

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