G2539
格列本脲
meets USP testing specifications
别名:
格列本脲, 5-氯-N-[4-(环己基脲磺酰)苯乙基]-2-甲氧基苯甲酰胺, N-对[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰基-N′-环己基脲
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关于此项目
经验公式（希尔记法）:
C23H28ClN3O5S
化学文摘社编号:
分子量:
494.00
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
233-570-6
MDL number:
产品名称
格列本脲, meets USP testing specifications
InChI key
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
InChI
1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
SMILES string
COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
agency
USP/NF
meets USP testing specifications
application(s)
pharmaceutical (small molecule)
storage temp.
2-8°C
Quality Level
Gene Information
human ... ABCC8(6833), KCNH2(3757), KCNJ11(3767)
rat ... Kcnj1(24521)
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hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Khac-Minh Thai et al.
Bioorganic & medicinal chemistry, 16(7), 4107-4119 (2008-02-05)
Acquired long QT syndrome causes severe cardiac side effects and represents a major problem in clinical studies of drug candidates. One of the reasons for development of arrhythmias related to long QT is inhibition of the human ether-a-go-go-related-gene (hERG) potassium
The effect of Glibenclamide on somatosensory evoked potentials after cardiac arrest in rats.
Lachance, et al.
Neurocritical Care, 36, 612-620 (2023)
Lisa D Marroquin et al.
Current protocols in toxicology, 71, 14-14 (2017-02-02)
The bile salt export pump (BSEP, ABCB11) belongs to the ATP-binding-cassette superfamily of transporters and is predominately found in the liver. BSEP is an efflux transporter that plays a critical role in the secretion of bile salts into the bile.
Jesse A Stokum et al.
Science signaling, 16(788), eadd6364-eadd6364 (2023-06-06)
Brain swelling causes morbidity and mortality in various brain injuries and diseases but lacks effective treatments. Brain swelling is linked to the influx of water into perivascular astrocytes through channels called aquaporins. Water accumulation in astrocytes increases their volume, which
Ruchira M Jha et al.
Journal of neurotrauma, 38(5), 628-645 (2020-11-19)
Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (TBI). Adult Sprague-Dawley rats underwent fluid percussion injury (FPI; n = 45), controlled cortical impact (CCI;
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