G4382
(±)-骨化醇-乙酸
analytical standard, crystalline complex consisting of equimolar quantities of gossypol and acetic acid, ~95%
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关于此项目
经验公式（希尔记法）:
C30H30O8 · C2H4O2
化学文摘社编号:
分子量:
578.61
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C30H30O8.C2H4O2/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36;1-2(3)4/h7-12,33-38H,1-6H3;1H3,(H,3,4)
SMILES string
CC(O)=O.CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O
InChI key
NIOHNDKHQHVLKA-UHFFFAOYSA-N
grade
analytical standard
assay
~95% (HPLC), ~95%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
food and beverages
format
neat
storage temp.
−20°C
Application
有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务部门。
Biochem/physiol Actions
据报道可以抑制胃蛋白酶原向胃蛋白酶的自溶转化。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hope M Amm et al.
Molecular cancer research : MCR, 9(4), 403-417 (2011-03-02)
TRA-8, a monoclonal antibody to death receptor 5 induces apoptosis in various cancer cells; however, the degree of sensitivity varies from highly sensitive to resistant. We have previously shown that resistance to TRA-8 can be reversed by using chemotherapeutic agents
Asli Kisim et al.
Journal of cancer research and clinical oncology, 138(7), 1155-1163 (2012-03-14)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce extrinsic pathway of apoptosis in many types of cancer cells. AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that
Natalie McGregor et al.
Journal of cellular biochemistry, 110(5), 1187-1194 (2010-07-01)
Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common treatment for advanced prostate cancer patients; however, ADT fails in nearly all cases resulting in castration resistant or androgen-insensitive (AI)
G Sonpavde et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 23(7), 1803-1808 (2011-11-25)
AT-101 (A), a small molecule oral inhibitor of the Bcl-2 family, has activity alone and in combination with docetaxel (Taxotere) and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC). A randomized, double-blind, placebo-controlled phase II trial compared DP combined with
Simone Fulda
Planta medica, 76(11), 1075-1079 (2010-05-21)
Natural products can exhibit many beneficial effects on human health. As far as cancer is concerned, naturally occurring compounds have been reported to prevent tumorigenesis and also to suppress the growth of established tumors. As cancer cells have evolved multiple
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