grade
analytical standard
drug control
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
CN1C(=O)NC(=O)C(C)(C1=O)C2=CCCCC2
InChI
1S/C12H16N2O3/c1-12(8-6-4-3-5-7-8)9(15)13-11(17)14(2)10(12)16/h6H,3-5,7H2,1-2H3,(H,13,15,17)
InChI key
UYXAWHWODHRRMR-UHFFFAOYSA-N
General description
Hexobarbital is a widely used drug to analyze the capacity and ability of the liver to metabolize drugs.
Application
Hexobarbital may be used as a reference standard for the determination of hexobarbital and its metabolites, 3′-hydroxyhexobarbital and 3′-keto-hexobarbital from the biological samples by high-performance liquid chromatography method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
静脉内麻醉药
Rapid analysis of hexobarbital and its main metabolites in mice by high-performance liquid chromatography.
Bocker R.
Journal of Chromatography. B, Biomedical Sciences and Applications, 228, 350-354 (1982)
Pharmacokinetics of hexobarbital in young and old rats.
Boonstra-Nieveld I H J, et al.
Mechanisms of Ageing and Development, 50(3), 289-298 (1989)
Martin Steinhaus et al.
Journal of agricultural and food chemistry, 57(7), 2882-2888 (2009-03-04)
Seventeen aroma-active volatiles, previously identified with high flavor dilution factors in fresh, pink Colombian guavas (Psidium guajava L.), were quantified by stable isotope dilution assays. On the basis of the quantitative data and odor thresholds in water, odor activity values
C D Sreedevi et al.
Journal of ethnopharmacology, 124(2), 171-175 (2009-05-09)
Sida acuta Burm. f. (Malvaceae) is used in Indian traditional medicine to treat liver disorders and is useful in treating nervous and urinary diseases and also disorders of the blood and bile. Evaluation of the hepatoprotective properties of the methanolic
Ozgür Devrim Can et al.
Phytotherapy research : PTR, 26(11), 1695-1700 (2012-03-08)
The present study was undertaken to investigate the putative activity of a methanol extract of Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and quercitrin (784 ppm) were identified as the major phenolic compounds in the extract. When administered
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