H102
氟哌啶醇代谢物 II
analytical standard
别名:
(±)-4-(4-Chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidinebutanol, 还原氟哌啶醇
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关于此项目
经验公式（希尔记法）:
C21H25ClFNO2
化学文摘社编号:
分子量:
377.88
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C21H25ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,20,25-26H,1-2,11-15H2
SMILES string
OC(CCCN1CCC(O)(CC1)c2ccc(Cl)cc2)c3ccc(F)cc3
InChI key
WNZBBTJFOIOEMP-UHFFFAOYSA-N
grade
analytical standard
assay
≥98% (HPLC)
form
solid
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
solubility
DMSO: 10 mg/mL
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
J M Leroux et al.
Progress in neuro-psychopharmacology & biological psychiatry, 18(2), 347-353 (1994-03-01)
1. The authors attempted to correlate plasma concentrations in H/rH and clinical efficacy from 8 schizophrenic patients (DSM IIIR) on H. 2. No significant correlations were found between H, rH plasma levels and positive and negative subscale for each patient.
H Hoja et al.
Journal of chromatography. B, Biomedical sciences and applications, 688(2), 275-280 (1997-01-24)
A sensitive and accurate liquid chromatographic-electrospray mass spectrometric (LC-ES-MS) method for the determination of haloperidol (H) and reduced haloperidol (RH) in human plasma is presented, using chlorohaloperidol as the internal standard. A 2-ml volume of plasma was subjected to basic
S Ulrich et al.
International clinical psychopharmacology, 14(4), 219-228 (1999-09-01)
The aim of this study was to investigate the effect of reduced haloperidol, the main metabolite of the antipsychotic drug haloperidol, on psychopathology improvement and extrapyramidal adverse effects in acute schizophrenia. The steady-state pharmacokinetics of reduced haloperidol was studied. Serum
J G Shin et al.
British journal of clinical pharmacology, 51(1), 45-52 (2001-02-13)
We evaluated the inhibitory effect of haloperidol and its metabolites on CYP2D6 activity in order to better understand the potential role of these metabolites in drug interactions involving haloperidol. The inhibitory effects of haloperidol and five of its metabolites on
K Mihara et al.
Therapeutic drug monitoring, 22(3), 245-249 (2000-06-13)
The effect of a genetic polymorphism of inducibility of cytochrome P450 (CYP) 1A2 on the steady state plasma concentrations (Css) of haloperidol and reduced haloperidol was studied to clarify if these Css are dependent on the CYP1A2 activity. The subjects
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