H102
氟哌啶醇代谢物 II
analytical standard
别名:
(±)-4-(4-Chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidinebutanol, 还原氟哌啶醇
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关于此项目
经验公式（希尔记法）:
C21H25ClFNO2
化学文摘社编号:
分子量:
377.88
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
氟哌啶醇代谢物 II, analytical standard
InChI
1S/C21H25ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,20,25-26H,1-2,11-15H2
SMILES string
OC(CCCN1CCC(O)(CC1)c2ccc(Cl)cc2)c3ccc(F)cc3
InChI key
WNZBBTJFOIOEMP-UHFFFAOYSA-N
grade
analytical standard
assay
≥98% (HPLC)
form
solid
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
color
white
solubility
DMSO: 10 mg/mL
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
D W Eyles et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(2), 127-129 (1998-06-10)
In vitro, cytosolic human ketone reductases catalyse the stereospecific (i.e. >99%) formation of S(-) reduced haloperidol (RHP) from haloperidol (HP). Whether this situation is reflected in patients taking the drug is unknown. In this study in nine patients taking HP
Naoya Kishikawa et al.
Analytical and bioanalytical chemistry, 386(3), 719-724 (2006-09-08)
A simultaneous method for the determination of haloperidol (HP) and its metabolite, reduced haloperidol (RHP), in human serum was developed by means of high-performance liquid chromatography (HPLC) with fluorescence detection. Suzuki coupling reaction with a fluorescent arylboronic acid, 4-(4,5-diphenyl-1H-imidazol-2-yl)phenylboronic acid
W H Chang et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 4(2), 119-126 (1994-06-01)
Plasma haloperidol (HL) and reduced haloperidol (RH) levels were measured in 60 schizophrenic patients treated with high to very high HL doses of 40-200 mg/day. Plasma samples were obtained at steady-state conditions and 10-12 h after the evening dose and
M Aravagiri et al.
Journal of chromatography. B, Biomedical applications, 656(2), 373-381 (1994-06-17)
A simple and highly sensitive liquid chromatographic method with electrochemical detection for the simultaneous determination of haloperidol and its metabolite reduced haloperidol in human plasma has been developed. The sample preparation for the analysis involves a simple one-step extraction procedure
D W Eyles et al.
Psychopharmacology, 116(2), 161-166 (1994-10-01)
In patients taking haloperidol (HP), circulating concentrations of reduced haloperidol (RHP increase disproportionately to the dose or concentration of the parent drug. In the current study, we tested the hypothesis that the nonlinearity is due to preferential saturation of the
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