I0627
异巴比妥酸
analytical standard
别名:
2,4,5-三羟基嘧啶, 5-羟基尿嘧啶
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关于此项目
经验公式（希尔记法）:
C4H4N2O3
化学文摘社编号:
分子量:
128.09
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
207-829-9
Beilstein/REAXYS Number:
127205
MDL number:
InChI key
FQXOOGHQVPKHPG-UHFFFAOYSA-N
InChI
1S/C4H4N2O3/c7-2-1-5-4(9)6-3(2)8/h1H2,(H2,5,6,8,9)
SMILES string
O=C1CNC(=O)NC1=O
grade
analytical standard
assay
~98%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
>300 °C (dec.) (lit.)
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Application
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Grégory Eot-Houllier et al.
Nucleic acids research, 33(1), 260-271 (2005-01-14)
Clustered DNA lesions, possibly induced by ionizing radiation, constitute a trial for repair processes. Indeed, recent studies suggest that repair of such lesions may be compromised, potentially leading to the formation of lethal double-strand breaks (DSBs). A complex multiply damaged
Grégory Eot-Houllier et al.
Nucleic acids research, 35(10), 3355-3366 (2007-05-01)
Evidence has emerged that repair of clustered DNA lesions may be compromised, possibly leading to the formation of double-strand breaks (DSB) and, thus, to deleterious events. The first repair event occurring at a multiply damaged site (MDS) is of major
Gunn A Hildrestrand et al.
Experimental cell research, 315(15), 2558-2567 (2009-05-30)
Adipose-tissue derived mesenchymal stem cells (AT-MSCs) are a promising tool for use in cell-based therapies. However, in vitro expansion is required to obtain clinically relevant cell numbers, and this might increase the chance of genomic instability. DNA repair is crucial
Philippe Simon et al.
Nucleic acids research, 34(13), 3660-3669 (2006-08-04)
5-Hydroxyuracil is a major oxidized nucleobase that can be generated by the action of (*)OH radical and one-electron oxidants. The latter modified base that exhibits a low ionization potential is highly susceptible to further degradation upon exposure to various oxidants.
Riccardo Amorati et al.
Organic letters, 12(18), 4130-4133 (2010-08-28)
Addition of millimolar amounts of a weak base (pyridines) dramatically accelerates the reaction with peroxyl radicals of two biologically relevant uracil derivatives, 5-hydroxyuracil (HU) and 5-hydroxy-6-methyluracil (HMU). This is due to the formation of small amounts of the deprotonated form
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