I3132
吲哚洛芬
analytical standard
别名:
α-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid
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关于此项目
经验公式（希尔记法）:
C17H15NO3
化学文摘社编号:
分子量:
281.31
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
250-833-0
MDL number:
InChI key
RJMIEHBSYVWVIN-UHFFFAOYSA-N
InChI
1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)
SMILES string
CC(C(O)=O)c1ccc(cc1)N2Cc3ccccc3C2=O
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Gene Information
human ... IL8RA(3577), PTGS1(5742), PTGS2(5743)
Application
Indoprofen is a non-steroidal drug, which can show a range of pharmacological properties such as analgesic and anti-inflammatory activities. Its mode of action involves the inhibition of prostaglandin synthesis.
Indoprofen may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Indoprofen may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Indoprofen is a non-steroidal drug, which can show a range of pharmacological properties such as analgesic and anti-inflammatory activities.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
P Failli et al.
British journal of pharmacology, 123(7), 1457-1463 (1998-05-14)
1. The effect of the NSAIDs indomethacin, indoprofen, diclofenac and acetylsalicylic acid on the increase in guanosine 3':5'-cyclic monophosphate (cyclic GMP) induced by nitric oxide-donor agents was tested in human whole platelets and in platelet crude homogenate. 2. In whole
Pharmacokinetics of the enantiomers of indoprofen in man
V T, et al.
International Journal of Clinical Pharmacology Research, 4(3), 223-230 (1984)
Nicholas J Lawrence et al.
The Journal of organic chemistry, 67(2), 457-464 (2002-01-19)
The intermediate anion derived from the vicarious nucleophilic substitution (VNS) of hydrogen reacts with a series of alkyl halides to generate the corresponding alpha-alkylated conventional VNS product in a one-pot process. This one-pot VNS-alkylation reaction offers a convenient route to
Determination of the enantiomers of indoprofen in blood plasma by high-performance liquid chromatography after rapid derivatization by means of ethyl chloroformate
Bjorkman S
Journal of Chromatography. B, Biomedical Applications, 339(2), 339-346 (1985)
B Przybilla et al.
Photo-dermatology, 4(2), 73-78 (1987-04-01)
The phototoxic activity of the non-steroidal anti-inflammatory drugs (NSAID) acetylsalicylic acid, benoxaprofen, carprofen, diclofenac, indoprofen, ketoprofen, tiaprofenic acid, and of thiophene, a heterocyclic ring structure of the tiaprofenic acid molecule, was evaluated in vitro by a newly developed photo-basophil-histamine-release test
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